灵芝孢子和抗性淀粉对糖尿病大鼠糖脂代谢及氧化应激的协同干预

Synergistic Intervention of Resistant Starch and Ganoderma lucidum Spore Powder on Glycolipid Metabolism and Oxidative Stress in Diabetic Rats

目的:探讨灵芝孢子和抗性淀粉对Ⅱ型糖尿病大鼠糖脂代谢及氧化应激的作用和机制。方法:采用链脲佐菌素诱导的方法建立Ⅱ型糖尿病模型,考察灵芝孢子和抗性淀粉对糖尿病大鼠的血糖、血脂及氧化应激指标的影响。结果:抗性淀粉和灵芝孢子均可改善糖尿病大鼠血糖水平,对抗糖尿病引起的氧化应激损伤。抗性淀粉降血糖、抗氧化作用较强,灵芝孢子粉调节大鼠脂代谢紊乱效果明显,抗性淀粉和灵芝孢子协同作用可进一步改善脂代谢水平,增强二者抗氧化能力。结论:抗性淀粉和灵芝孢子粉协同干预模式和传送方式可有效降低糖尿病大鼠的血糖水平,改善脂代谢紊乱,提高抗氧化应激的能力,可作为一种较好的减缓糖尿病症状的有效饮食干预方法。

Objective: To investigate the mechanism of action of resistant starch(RS) and Ganoderma lucidum spore powder(GLSP) on glycolipid metabolism and oxidative stress in type 2 diabetic rats. Methods: Diabetic rats were induced by streptozocin(STZ). The effects of RS and GLSP on blood glucose, blood lipid and oxidative stress index were investigated. Results: RS and GLSP could improve the content of blood glucose and exert antioxidant effect. While RS had stronger antioxidant capability than GLSP, GLSP had an advantage in improving lipid metabolism disorder over RS and there was a synergistic effect between them. The antioxidant capacity was further enhanced through the intervention with RS. Conclusion: The mode of synergistic intervention and simultaneous consumption of RS and GLSP can effectively reduce blood glucose, improve lipid metabolism, and enhance antioxidant capability. This mode is a better dietary intervention method of preventing diabetes and improving diabetic symptoms.