摘要
硫酸化修饰多糖是一类糖羟基上含有硫酸根的大分子生物活性物质,具有抗肿瘤等多种重要的生物功能活性。硫酸化多糖的抗肿瘤活性与其结构有密切联系,如取代度、分子质量和硫酸基团的取代位置等,而引起其抗肿瘤活性的分子机制也是近年来研究的热点。本文根据硫酸化修饰多糖的研究现状,对其硫酸化修饰的主要方法及抗肿瘤活性的构效关系和分子机制进行综述,并对硫酸化多糖的深入研究做出展望。
Sulfated polysaccharides is a class of macromolecular bioactive compounds with saccharide hydroxyl groups containing sulfate ions which have a variety of important biological functions such as antitumor activity. The antitumor activity of sulfated polysaccharides is highly associated with their structural characteristics, such as degree of substitution, molecular weight and the substitute positions for sulfate groups. In recent years, the molecular mechanisms of the antitumor activity have become a research focus. This paper presents the current state of research on sulfated polysaccharides and reviews methods for sulfated modification of polysaccharides as well as the structure-antitumor activity relationship of the modified polysaccharides and the molecular mechanisms involved in the antitumor activity. Additionally, future research trends are discussed.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2014年第23期297-302,共6页
Food Science
基金
国家自然科学基金面上项目(31271825)
关键词
硫酸化多糖
构效关系
抗肿瘤活性
分子机制
sulfated polysaccharide
structure-activity relationship
antitumor activity
molecular mechanisms