食物活性成分结肠靶向输送系统研究进展

Progress in Preparation and Application of Colon-Specific Delivery Systems for Food Bioactive Components

随着肠道菌群的发现及其健康促进功能的明确,使得结肠的营养及健康状况受到大量关注。以结肠靶向输送体系为载体经口服主动向结肠递送食物活性成分,能够达到优化肠道菌群和/或维护结肠健康的效果。因此,食物活性成分结肠靶向输送体系是结肠功能性食品研发或结肠营养支持的技术核心。在查阅近10年相关文献的基础上,本文着重对食物活性成分(益生菌、疏水小分子活性物质、亲水小分子活性物质和大分子活性物质)结肠靶向输送体系的构建原理(p H敏感型输送系统、时间依赖型输送系统、菌群/酶触发型输送系统和其他类型输送系统)及其应用现状进行综述,并就食物活性成分结肠靶向输送体系研究开发所存在的问题及其发展方向进行阐述。

With the identification of the intestinal flora and its health-enhancing functions, the nutritional and health status of the colon have attracted considerable attention. The colonic flora could be regulated by a colon-specific delivery system for food bioactive components through oral ingestion. In this way, the health of the colon can be protected. In this context, the colon-specific delivery system for food bioactive components is the core technology for developing colonic functional foods and providing nutritional support for the colon. This paper reviews the literature over the last decade concerning the principles for constructing p H-dependent, time-dependent or bacteria-dependent colon-specific delivery systems for food bioactive components such as probiotics, small hydrophobic and hydrophilic bioactive substances, and bioactive macromolecules as well as their current applications. Furthermore, the current problems and future research directions of colon-specific delivery system for food bioactive components are also discussed.