高剂量二甲基甘氨酸钠对肉鸡生产性能、血常规和血液生理生化指标的影响

Effect of High-Dose N,N-Dimethylglycine Sodium on Growth Performance, Hematological Parameters and Blood Physiobiochemical Indices of Broilers

研究日粮中添加高剂量食品添加剂二甲基甘氨酸钠对肉鸡生产性能、血常规和血液生理生化指标的影响。实验选择1日龄爱拔益加(Arbor Acres,AA)肉鸡480只,随机分为4个处理组,每组6个重复,每个重复20只肉鸡,实验期分为1~21 d(前期)和22~42 d(后期)。对照组饲喂基础日粮,实验组为在基础日粮中分别添加1 500、7 500、15000mg/kg的二甲基甘氨酸钠。结果表明:1)日粮中添加1500mg/kg的二甲基甘氨酸钠显著降低了肉鸡前期耗料与体质量增加量比(P<0.05);实验后期,15000mg/kg组肉鸡的耗料与体质量增加量比显著高于1500mg/kg组和7500mg/kg组(P<0.05)。从全期来看,7500mg/kg组和15000mg/kg组肉鸡的平均体质量日增加量与对照组相比差异均不显著(P>0.05)。2)不同添加剂量的二甲基甘氨酸钠对21日龄和42日龄肉鸡的血常规指标较对照组均没有显著差异(P>0.05)。3)前期15000mg/kg组肉鸡的总蛋白含量和白蛋白含量显著低于对照组(P<0.05)。后期15000mg/kg组肉鸡血液中的总胆红素极显著高于对照组、1500mg/kg组和7500mg/kg组(P<0.01)。综上所述,15000mg/kg的二甲基甘氨酸钠可对肉鸡的消化吸收和肝功能造成一定的损伤,应用时应严格按规定控制用量。

The main objective of this study was to evaluate the effect of high-dose N,N-dimethylglycine sodium (Na-DMG) on growth performance, hematological parameters and blood physiobiochemical indices of broilers. Totally 480 one-day-old Arbor Acres (AA) broiler chicks were randomly allocated to four groups with 6 replicates in each group, and fed commercial diet supplemented with N,N-dimethylglycine sodium at doses of 1 500, 7 500 and 15 000 mg/kg, respectively, for 42 days, which was divided into early (1 21 d) and later (22 42 d) stages. The results showed that: 1) the dietary addition of 1 500 mg/kg N,N-dimethylglycine sodium could decrease the feed gain ratio of 21-day-old broilers significantly (P < 0.05). N,N-dimethylglycine sodium at 15 000 mg/kg could result in the increased the feed gain ratio of 42-day-old broilers when compared with 1 500 and 7 500 mg/kg (P < 0.05). Throughout the whole administration period, no significant difference in feed gain ratio among the control group, 7 500 mg/kg and 15 000 mg/kg groups was observed (P > 0.05); (2) different dose levels of dietary supplementation with N,N-dimethylglycine sodium had no significant difference in hematological parameters of broilers when compared with the control group (P >0.05); 3) feeding with 15 000 mg/kg N,N-dimethylglycine sodium decreased blood total protein and albumin levels of 21-day-old broilers significantly when compared with the control group (P < 0.05), while total bilirubin in the blood from the 15 000 mg/kg group was significantly higher than that from the control, 1 500 mg/kg and 7 500 mg/kg groups (P < 0.01). In conclusion, the dietary addition of 15 000 mg/kg N,N-dimethylglycine sodium can damage digestible absorption and liver function of broilers.