灵芝菌丝体液态发酵及多糖药理活性研究进展

Recent Progress in Pharmacological Activities of Polysaccharides from the Mycelia of Liquid-Cultured Ganoderma lucidum

灵芝是一种珍贵的药食两用真菌,具有补中益气、滋补强壮、扶正固本、延年益寿等功效。灵芝多糖是从灵芝子实体或液态发酵灵芝菌丝体中提取分离而获得的多糖,具有抗肿瘤、免疫调节、保肝护肝、抗氧化、抗疲劳、清除自由基和抗衰老等药理活性。本文对近年来灵芝的液态发酵过程中菌种选育、培养基和发酵条件优化以及灵芝多糖的药理活性研究进行系统综述。

Ganoderma lucidum is a mushroom widely used in China as a traditional Chinese medicine and healthy food for thousands of years due to its promotion of longevity and health. Polysaccharides extracted from fruit bodies or liquidcultured mycelia of G. lucidum have anti-tumor, immune-improving, liver-protecting, anti-oxidation, anti-fatigue, free radical scavenging and anti-aging functions. In this paper, we provide a systematic review of studies on strain breeding and culture medium and conditions optimization for the production of G. lucidum polysaccharides as well as their pharmacological activities.