摘要
随着阿尔茨海默病(AD)预防与干预性研究的深入,运动已逐步发展为AD继药物治疗之后的第二种干预手段。近年来人们发现,运动不仅可对单纯性AD起到干预作用,同时也在APOE 4-AD中发挥着一定作用,但相关机制并不清楚。本文以APOE 4为切入点,总结收集近几年相关研究成果,进一步剖析运动、APOE 4与SAD之间相互作用机制。并在此基础上提出假设即:运动是否是通过直接作用APOE4而对SAD病理进程起到一个整体的调节作用,为AD的防治提供新的思路。
With the deepening of prevention and intervention research of Alzheimer’s Disease (AD),sports has gradually developed as the second intervention method after drug treatment for AD.In recent years,it has been found that sports not only has intervening effect on AD,but at the same time has some effect on APOEε4 -AD;yet the mechanism is not clear.With APOEε4 as the breakthrough point,this article collects related research results in recent years to further analyze the mutual interaction mechanism among sports,APOEε4 and SAD.On such basis,the paper proposes the assumption:whether exercise directly works on APOEε4,thus generally regulating SAD pathological processes.The paper aims to provide new thoughts for AD prevention and controlling.
出处
《体育科技文献通报》
2016年第1期3-4,共2页
Bulletin of Sport Science & Technology
基金
青少年健康评价与运动干预教育部重点实验室建设项目(项目编号:40500-541235-14203/004)
