红曲蜂胶片辅助降血脂功能的研究

Research on Hypolipidemic Effect of Monascus and Propolis Tablet

研究红曲蜂胶片对高脂血症模型大鼠血脂及脂蛋白的影响。将50只SD大鼠随机分为5组,分别为空白对照组、高脂血症模型组和红曲蜂胶片低、中、高剂量组(0.17、0.33、1.00 g/kg,分别相当于人推荐摄入量的5、10、30倍),每组10只。各组每日灌胃相应的受试物或溶剂,连续灌胃6周。模型组大鼠总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)和低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)含量均显著升高(P<0.01)。与模型组比较,中剂量组大鼠血清LDL-C含量,中、高剂量组大鼠血清TG含量均明显降低(P<0.05),差异均有统计学意义。证明红曲蜂胶片具有辅助降血脂功能。

The hypolipidemic effect of monascus and propolis tablet(MPT)on experimental rats was studied.50 SD rats were randomly divided into 5 groups:control group,hyperlipidemia model group and low,middle and high dose of monascus and propolis tablet groups(0.17,0.33,1.00 g/kg equivalent to 5,10 and 30 times of the recommended dose of human respectively),each with 10.All the groups were administered with their own test substance by gavage for 6 weeks.Compared with the control group,serm total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)in model group were increased significantly(P<0.01).Compared with the model group,LDL-C level in the serum of rats in middle dose group and TG level in the serum of rats in middle and high dose groups were obviously decreased(P<0.05),the differences were statistically significant.The Monascus and propolis Tablet could decrease the serum lipid level effectively.