流感病毒感染对不同年龄人群肠道菌群影响

Effects of influenza virus infection on intestinal flora among different age groups

目的流感严重威胁人类的生命健康,至今仍然是人类常见的致死性传染病。部分流感对象会出现明显的腹泻等胃肠反应相关症状,分析流感病毒感染对肠道菌群的影响,为腹泻等并发症的防控提供依据。方法选取2017-01-01-2018-04-30秦皇岛市第一医院诊断为流行性感冒的患者为病例组。按照年龄、性别频率匹配的原则选取等量健康人为对照组。采集粪便进行优势菌鉴定、含量分析。对比病例组与对照组<14、14～60和>60岁亚组的菌属数量水平。结果病例组<14、14～60、>60岁亚组大肠埃希菌含量水平高于对照组,差异有统计学意义,P<0.05。病例组14～60岁大肠埃希菌含量高于<14和>60岁,对照组<14岁大肠埃希菌菌含量低于14～60和>60岁,差异有统计学意义,均P<0.05。<14岁大肠埃希菌含量上升水平最高,其次为14～60岁,再次为>60岁。病例组<14岁乳杆菌属含量高于14～60和>60岁,对照组<14岁乳杆菌属含量高于>60岁,差异有统计学意义,均P<0.05。<14、14～60、>60岁乳杆菌含量基本相同。病例组<14、14～60、>60岁乳杆菌属含量低于对照组,差异有统计学意义,均P<0.05。病例组<14、14～60、>60岁双歧杆菌属含量低于对照组,差异有统计学意义,均P<0.05。病例组<14岁双歧杆菌属含量高于14～60和>60岁,对照组<14岁双歧杆菌属含量高于14～60岁,14～60岁高于>60岁,差异有统计学意义,均P<0.05。结论流感病毒感染会导致大肠埃希菌、乳杆菌属、双歧杆菌属含量变化,其中<14岁的变化相对显著。

OBJECTIVE Influenza seriously threatens human life and health,which is still a common lethal infectious disease in human beings.Some patients with influenza have obvious gastrointestinal symptoms such as diarrhea.The study is to analyze the effect of influenza virus infection on intestinal flora and provide evidence for prevention and control of diarrhea and other complications.METHODS Influenza patients diagnosed in the first Hospital of Qinhuangdao City from January 1,2017 to April 30,2018 were selected as the case group.According to the principle of age and gender frequency matching,the same amount of healthy people were selected as the control group.Feces were collected for identification and analysis of dominant bacteria.The number of bacteria of less than 14 years old,14-60 years old and more than60 years old subgroup were compared in both the case group and the control group.RESULTS The level of Escherichia coli in case group less than 14,14-60,and over 60 years old was higher than that in the control group.The difference was statistically significant(P<0.05).The number of Escherichia coli of 14-60 years old patients in the case group was higher than that of other subgroup.The number of Escherichia coli of less than 14 years old people in the control group were lower than that of other subgroup,and the difference was statistically significant(P<0.05).The level of Escherichia coli increased the highest in less than 14 years old subgroup,followed by 14-60 years old and over 60 years old subgroup.The Lactobacillus content of subgroups in case group was lower than that of the control group,the difference was statistically significant(P<0.05).The content of Lactobacillus was basically the same at less than 14,14-60 and over 60 years old.The Bifidobacterium content of subgroups in the case group were lower than those in the control group.The Bifidobacterium content of less than 14 years old subgroup in the case group was higher than that in other two subgroups.It was the same in the control group.The difference was statistically significant(all P<0.05).CONCLUSIONS Influenza virus infection can cause changes in Escherichia coli,Lactobacillus and Bifidobacterium.The change is more significant for those under 14 years of age.