复方樟柳碱对改善眼底病患者视力影响

Effect of compound anisodine on improving eyesight of fundus diseases

目的眼底病变与高血压和血液黏稠度高等因素有关,患者多伴有血流动力学异常,复方樟柳碱具有血管扩张作用,本研究分析复方樟柳碱临床治疗眼底疾病的效果及对视力的影响。方法选取2017-01-01-2017-12-31沈阳爱尓眼视光医院眼科收治的90例眼底疾病患者为研究对象,根据患者年龄、性别、病程、发病位置等因素,在两种治疗方法中选择研究组和对照组,各45例。对照组患者行常规治疗,研究组患者在常规治疗基础上行复方樟柳碱进行治疗。对比两组患者临床血流动力学指标、治疗效果和视力变化等情况。结果治疗后,研究组全血黏度(whole blood viscosity,WBV)水平为(4.51±0.33)mpa.s,低于对照组的(4.85±0.32)mpa.s,差异有统计学意义,t=4.962,P<0.001;研究组红细胞聚集指数(red cell assembling index,RAI)水平为4.11±0.31,低于对照组的4.42±0.34,差异有统计学意义,t=4.520,P<0.001;研究组血细胞比容(haematocrit,HCT)为(0.33±0.02)%,低于对照组的(0.42±0.01)%,差异有统计学意义,t=24.000,P<0.001;研究组纤维蛋白原(fibrinogen,FIB)为(2.73±0.44)g/L,低于对照组的(3.75±0.42)g/L,差异有统计学意义,t=11.249,P<0.001。研究组治疗总有效率为95.56%,高于对照组的77.78%,差异有统计学意义,χ~2=6.154,P=0.013;研究组视力轻度低下比例为71.11%,明显高于对照组的46.67%,差异有统计学意义,χ~2=6.719,P=0.035。结论临床上采用复方樟柳碱治疗眼底疾病效果显著,可显著提升患者视力水平,改善患者血流动力学指标,安全性能良好。

OBJECTIVE Fundus disease is related to hypertension and blood viscosity.Most of the patients have abnormal hemodynamics.Compound anisodine has vasodilation effect.This study analyzes the effect of compound anisodine in the treatment of fundus diseases and visual effects.METHODS 90 cases with fundus diseases admitted to our hospital from January 1,2017 to December 31,2017 were selected as the study subjects.The subjects were divided into control group and research group(45 cases each)by treatment method.The control group was given routine treatment.The study group was given compound anisodine on the basis of routine treatment.The hemodynamic indexes,therapeutic effect and visual acuity of the two groups were compared.RESULTS After treatment,the level of whole blood viscosity(WBV)in the study group(4.51±0.33)mpa.s was lower than that in the control group(4.85±0.32)mpa.s.The difference was statistically significant(t=4.962,P<0.001).The level of red cell assembling index(RAI)in the study group(4.11±0.31)was lower than that in the control group(4.42±0.34).The difference was statistically significant(t=4.520,P<0.001).The level of haematocrit(HCT)in the study group(0.33±0.02)%was lower than that in the control group(0.42±0.01)%.The difference was statistically significant(t=24.000,P<0.001).The level of fibrinogen(FIB)in the study group(2.73±0.44)g/L was lower than that in the control group(3.75±0.42)g/L.The difference was statistically significant(t=11.249,P<0.001).The total effective rate in the study group(95.56%)was higher than that in the control group(77.78%).The difference was statistically significant(χ~2=6.154,P=0.013).The visual acuity in the study group(71.11%)was lower than that in the control group(46.67%).The difference was statistically significant(χ~2=6.719,P=0.035).CONCLUSIONS Compound anisodine is effective in the treatment of fundus diseases.It can significantly improve visual acuity and hemodynamic parameters.It is safe and worthy of clinical application.