体质量指数及腰臀比对子宫肌瘤患病影响探讨

Effect of body mass index and waist-hip ratio on prevalence rate of ruterine leiomyoma

目的 雌激素在子宫肌瘤发生中具有重要作用,而脂肪可影响雌激素代谢。本研究探讨不同体质量指数及腰臀比对子宫肌瘤患病影响。方法 选取2016-03-01-2019-03-01滑县人民医院妇科查体的2 362名女性作为研究对象,按照体质量指数(body mass index,BMI)分为过轻(n=175)、正常(n=1 460)、过重(n=596)及肥胖(n=131),按腰臀比分为腹型肥胖(n=951)及非腹型肥胖(n=1 411)。统计子宫肌瘤患病人数,分析BMI、腰臀比与子宫肌瘤患病率相关性。结果 2 362名女性中,检出子宫肌瘤587例,占24.85%。随BMI增大,子宫肌瘤患病率逐渐升高,χ~2=12.349,P=0.006;腹型肥胖女性子宫肌瘤患病率为29.86%,高于非腹型肥胖女性的21.47%,χ~2=21.409,P<0.001。Pearson相关性分析结果显示,BMI(r=0.745,P=0.026)和腰臀比(r=0.720,P=0.038)与子宫肌瘤患病率呈正相关。结论 女性子宫肌瘤患病率随BMI增长而升高,且腰臀比升高可能会增加子宫肌瘤发病风险。建议腹型肥胖女性注意饮食和运动,降低BMI,预防子宫肌瘤发生。

OBJECTIVE Estrogen plays an important role in the development of uterine leiomyoma,and fat can affect the metabolism of estrogen.This study aims to investigate the effect of different body mass index(BMI)and waist-hip ratio on prevalence rate of uterine leiomyoma.METHODS Totally 2 362women who underwent gynecological examination in our hospital from March 1,2016to March 1,2019were selected as the subjects of study.They were divided into light(n=175),normal(n=1 460),overweight(n=596),obesity(n=131)according to BMI,and were divided into abdominal obesity(n=951)and non-abdominal obesity(n=1 411)according to waist-hip ratio.The prevalence rate of uterine leiomyoma was counted,and the correlation between BMI,waist-hip ratio and the prevalence rate of uterine leiomyoma was analyzed.RESULTS Totally 587cases of uterine fibroids were detected in 2 362women,accounting for 24.85%.With the increase of BMI,the prevalence of uterine fibroids gradually increased,χ2=12.349,P=0.006.The prevalence of uterine fibroids in abdominal obese women was 29.86%,which was higher than that of non-abdominal obese women(21.47%),χ2=21.409,P<0.001.Pearson correlation analysis showed that BMI(r=0.745,P=0.026)and waist-hip ratio(r=0.720,P=0.038)were positively correlated with the prevalence of uterine fibroids.CONCLUSIONS The prevalence of female uterine fibroids increases with the increase of BMI,and the increase of waist-hip ratio may increase the risk of uterine fibroids.It is recommended that obese women should pay attention to diet and exercise,decrease BMI and prevent uterine fibroids.