“树脂-捕获-释放”技术在有机合成中的应用

Resin-Capture-Release" Technique in Organic Synthesis

”树脂 -捕获 -释放”技术使用功能化聚合物清除剂选择性地吸附目标产物 ,液相组合合成小分子化合物库 .这一技术结合了固相和液相的优点 ,操作简便、快捷 ,反应容易控制 ,产物易分离 ,且产率高 ,纯度好 .

The 'resin-capture-release' hybrid technique, which has merged the merits of solid and solution phase synthesis, allows solution-phase synthesis of small molecular libraries and uses functionalized polymer scavenger to trap selectively the desired products away from solution phase reagents or byproducts. The method is simple, rapid, and easy manipulation and isolation.