慢性心力衰竭患者血清sST2、IL-6和肽素水平的变化及临床意义

Changes and Clinical Significance of Serum Levels of sST2, IL-6 and Peptide in Patients with Chronic Heart Failure

目的:探讨慢性心力衰竭(CHF)患者血清可溶性人基质裂解素2(sST2)、白细胞介素-6(IL-6)、和肽素水平的变化及临床意义。方法:选取2017年1月-2018年1月期间我院收治的CHF患者122例纳入CHF组,根据纽约心脏协会(NYHA)心功能分级将患者分为II级组34例,III级组48例,IV级组40例。另选取同期住院的心律失常非CHF患者35例为对照组。检测并比较CHF组与对照组患者血清sST2、和肽素、IL-6水平,比较不同NYHA心功能分级CHF患者血清sST2、和肽素、IL-6水平,采用Pearson相关性分析血清sST2、IL-6及和肽素三指标间的相关性。结果:CHF组患者血清sST2、和肽素、IL-6水平均高于对照组,差异有统计学意义(P<0.05)。不同NYHA心功能分级的CHF患者血清sST2、和肽素、IL-6水平整体比较差异均有统计学意义(P<0.05),IV级组、III级组患者血清sST2、和肽素、IL-6水平均高于II级组患者,且IV级组高于III级组,差异有统计学意义(P<0.05)。经Pearson相关性分析显示,血清sST2、IL-6水平与和肽素均呈正相关性(P<0.05)。结论:血清sST2、和肽素、IL-6水平与CHF的严重程度密切相关,可考虑将其作为临床诊断CHF的生物学指标。

Objective: To investigate the changes and clinical significance of serum levels of Soluble human matrix lysin 2(sST2),Interleukin-6(IL-6) and peptide in patients with chronic heart failure(CHF). Methods: 122 cases of CHF patients who were admitted in our hospital from January 2017 to January 2018 were included in CHF group. According to the New York Heart Association(NYHA),the patients were divided into II group with 34 cases, III group with 48 cases and IV group with 40 cases. Another 35 non arrhythmic patients hospitalized in the same period were selected as control group in the same period. The serum levels of sST2, peptide and IL-6 were detected and compared between the CHF group and the control group. The serum sST2, peptide and IL-6 levels in CHF patients with different NYHA heart function classification were compared, the correlation between serum sST2, IL-6 and peptide were analyzed by Pearson correlation analysis. Results: The serum levels of sST2, peptide and IL-6 in CHF group were higher than those in control group(P<0.05).There were significant differences in serum sST2, peptide and IL-6 levels in CHF patients with different NYHA cardiac function grades(P<0.05). The serum levels of sST2, peptide and IL-6 in the IV group and III group were higher than those in the II group, and the IV group was higher than that of the III group, the differences were statistically significant(P<0.05). Pearson correlation analysis showed that serum sST2 and IL-6 levels were positively correlated with peptide(P<0.05). Conclusion: The levels of serum sST2, peptide and IL-6is closely related to the severity of CHF. It can be used as biological indexes for clinical diagnosis of CHF.