围手术期介入治疗对伽玛刀治疗肝癌肝硬化临床疗效及预后的影响

Effect of Perioperative Interventional Therapy on the Gamma Knife in the Treatment of Hepatocellular Cirrhosis and Its Prognosis

目的:探究围手术期介入治疗对伽玛刀治疗肝癌肝硬化临床疗效及预后的影响。方法:选取2013年1月～2015年1月在我院就诊的肝癌肝硬化患者共61例,按照随机数字表法分为对照组(30例)和观察组(31例),对照组患者仅进行伽玛刀治疗,观察组患者进行围手术期介入治疗联合伽玛刀治疗,比较两组患者治疗后的总有效率、治疗后1年和3年的生存率以及不良反应的发生情况。结果:观察组患者治疗后总有效率为77.4%,显著高于对照组(53.3%,P<0.05);观察组治疗后1年和3年生存率分别为74.2%、45.2%,均显著高于对照组(53.3%、20.0%,P<0.05);两组患者治疗后均发生不同程度的不良反应,但经对症治疗均有效好转,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:围手术期介入治疗联合伽玛刀治疗肝癌患者可以有效提高治疗的总有效率以及治疗后1年和3年的生存率,且安全性好。

Objective: To explore the effect of perioperative interventional therapy on the clinical efficacy and prognosis of gamma knife radiosurgery for liver cirrhosis. Methods: 61 cases of patients with liver cirrhosis treated in our hospital from January 2013 to January 2015 were divided into the control group(30 cases) and the observation group(31 cases). The patients in control group were treated with gamma knife alone. The patients in observation group were treated with gamma knife treatment in the perioperative period. The total effective rate, 1-and 3-year survival rate and incidence of adverse reactions after treatment were observed and compared between two groups. Results: After treatment, the total effective rate of observation group was 77.4%, which was significantly higher than that of the control group(53.3%, P<0.05). The 1-and 3-year survival rates of observation group were 74.2% and 45.2%, respectively, which were significantly higher than those of the control group(53.3% and 20%, P<0.05). After treatment, various adverse reactions were found in both groups, but there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion:Interventional therapy combined with gamma knife can effectively improve the total effective rate and the 1-and 3-year survival rates in the treatment of liver cancer patients, and there is no significant increase in the incidence of adverse reactions with good safety.