川崎病患儿血浆中可溶性内皮细胞蛋白C受体、一氧化氮的表达及与炎症反应和冠状动脉病变的关系

Expression of Plasma Soluble Endothelial Protein C Receptor and Nitric Oxide in Children with Kawasaki Disease and its Relationship with Inflammatory Reaction and Coronary Artery Disease

目的:研究川崎病患儿血浆中可溶性内皮细胞蛋白C受体(s EPCR)、一氧化氮(NO)的表达及与炎症反应和冠状动脉病变(CAL)的关系。方法:选择2016年12月至2018年2月盘锦市中心医院收治的川崎病患儿104例为川崎病组,根据患儿彩色超声心动图检测结果将川崎病组分为CAL组30例和非CAL组(NCAL组)74例。另选取同期于我院进行体检的健康儿童56例为对照组。比较川崎病组与对照组、川崎病组患儿急性期与缓解期、CAL组与NCAL组s EPCR、NO、C-反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,并分析川崎病患儿s EPCR、NO与炎症因子及CAL的相关性。结果:川崎病组患儿s EPCR、NO、CRP、IL-6、TNF-α水平均高于对照组,差异有统计学意义(P<0.05)。川崎病组患儿急性期s EPCR、NO、CRP、IL-6、TNF-α水平均高于缓解期,差异有统计学意义(P<0.05)。CAL组s EPCR、NO、CRP、IL-6、TNF-α水平均高于NCAL组,差异有统计学意义(P<0.05)。经Pearson相关性分析结果显示,川崎病患儿s EPCR、NO与CRP、IL-6、TNF-α及CAL均呈正相关(P<0.05)。结论:川崎病患儿s EPCR、NO水平与炎性因子及CAL相关,s EPCR、NO可能在其炎症反应及CAL进展中起到一定的作用。

Objective: To study the expression of plasma soluble endothelial protein C receptor(s EPCR) and nitric oxide(NO) in children with Kawasaki disease and its relationship with inflammatory reaction and coronary artery disease(CAL). Methods: 104 children with Kawasaki disease who were treated in Central Hospital of Panjin from December 2016 to February 2018 were selected as Kawasaki disease group, according to the results of color echocardiography, the children of Kawasaki disease group were divided into CAL group with 30 cases and non CAL group(NCAL group) with 74 cases. In addition, 56 healthy children who were received healthy physical examination in our hospital at the same time were selected as the control group. The levels of s EPCR, NO, C-reactive protein(CRP), interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) were compared between the Kawasaki disease group and the control group, the acute stage and remission stage of children in the Kawasaki disease group, the CAL group and the NCAL group. The correlation of s EPCR, NO and inflammatory factors, CAL of Kawasaki disease were analyzed. Results: The levels of s EPCR, NO, CRP, IL-6, TNF-α of Kawasaki disease group were higher than the control group,the difference was statistically significant(P<0.05).The levels of s EPCR, NO, CRP,TNF-α, IL-6 in acute stage of Kawasaki disease group were higher than those in remission stage, the difference was statistically significant(P<0.05). The levels of s EPCR, NO, CRP, TNF-α and IL-6 in CAL group were higher than those in NCAL group, and the difference was statistically significant(P<0.05). The results of Pearson correlation analysis showed that s EPCR and NO were positively correlated with CRP, IL-6, TNF-α and CAL in children with Kawasaki disease(P<0.05). Conclusion: The levels of s EPCR and NO in children with Kawasaki disease are related to inflammatory factors and CAL, s EPCR and NO may play a certain role in its inflammatory response and CAL progression.