骨康胶囊联合玻璃酸钠注射液治疗骨性关节炎的疗效及对炎症反应的影响

Effect of Gukang Capsule combined with Sodium Hyaluronate Injection in the Treatment of Osteoarthritis and Its Effect on Inflammatory Reaction

目的:探讨骨康胶囊联合玻璃酸钠注射液治疗骨性关节炎的疗效,及其对机体炎性应激反应的影响。方法:将110例骨性关节炎患者依据随机数据表法分为对照组和观察组,每组患者55例,给予对照组患者玻璃酸钠注射液治疗,给予观察组患者骨康胶囊联合玻璃酸钠注射液治疗,比较治疗后的总有效率,临床症状评分、炎症因子及不良反应发生率。结果:观察组治疗总有效率为90.91%,显著高于对照组70.91%,差异有统计学意义(x2=7.308,P<0.05);治疗前两组间Lysholm评分、VAS评分、TNF-α及CRP水平对比差异无显著性(P>0.05);观察组治疗后Lysholm评分显著高于对照组,VAS评分、TNF-α及CRP水平显著低于对照组,差异有统计学意义(P<0.05);药物不良反应发生率比较,差异无统计学意义(x2=0.121,P=0.728)。结论:骨康胶囊与玻璃酸钠注射液联合治疗方案,可有效提高骨性关节炎的临床治疗效果,改善患者临床症状,降低炎性应激反应,安全性较高,具有一定的临床价值。

Objective: To investigate the effect of Gukang capsule combined with Sodium Hyaluronate Injection treatment of osteoarthritis, and its influence on inflammatory reaction stress. Methods: A total of 110 cases of osteoarthritis patients were selected as the research object, based on the random data table they were divided into control group and observation group, 55 cases in each group, patients in the control group were treated with Sodium Hyaluronate Injection treatment, observation group of patients were treated with Gukang capsule combined with Sodium Hyaluronate Injection treatment, the total effective rate, the clinical symptom score, the inflammatory factor and the incidence of adverse reaction after treatment were compared. Results: The total effective rate of treatment in the observation group was 90.91%, which was significantly higher than that of the control group(70.91%), and the difference was statistically significant(x2=7.308, P<0.05). There was no significant difference in Lysholm score, VAS score, TNF-α and CRP level between the two groups before treatment(P>0.05). The Lysholm score of the observation group was significantly higher than that of the control group.The VAS score, TNF-α and CRP were significantly lower than those in the control group, and the difference was statistically significant(P<0.05). There was no significant difference in the incidence of adverse drug reactions between the two groups(x2=0.121, P=0.728).Conclusion: Gukang capsule combined with Sodium Hyaluronate Injection, can effectively improve the osteoarthritis of clinical therapeutic effect, improve the patients clinical symptoms, reducing the inflammatory response to stress, high safety, which has a certain clinical value.