血清B型脑钠肽、糖类抗原125及甲状腺激素水平与慢性心力衰竭患者心功能的相关性研究

Correlation of Serum brain Natriuretic Peptide, Carbohydrate Antigen 125 and Thyroid Hormone Levels with Cardiac Function in Patients with Chronic Heart Failure

目的:探究慢性心力衰竭(CHF)患者血清B型脑钠肽(BNP)、糖类抗原125(CA125)和甲状腺激素(TH)水平与心功能的相关性。方法:选取2015年12月-2017年12月我院收治的120例CHF患者作为本次研究的对象,患者的心功能分级状况为纽约心脏病协会(NYHA)Ⅰ/Ⅱ级51例、NYHAⅢ级39例、NYHAⅣ级30例,另选取同期在我院接受体检的健康志愿者40例作为对照组。检测所有研究对象的血清BNP、CA125和TH水平,并分析其与患者左心室射血分数(LVEF)、左室舒张末内径(LVEDD)间的关系。结果:不同心功能分级患者血清BNP、CA125水平均显著高于对照组,且BNP、CA125水平随NYHA分级升高而逐渐升高(P<0.05)。NYHAⅢ级、NYHAⅣ级患者的血清T3水平显著低于对照组,且T3水平随NYHA分级升高而逐渐降低,各组间比较差异有统计学意义(P<0.05)。Pearson分析结果显示,CHF患者血清BNP、CA125水平与LVEF呈负相关(P<0.05),而与LVEDD呈正相关(P<0.05);血清T3水平与LVEF呈正相关(P<0.05),与LVEDD呈负相关(P<0.05)。结论:CHF患者血清BNP、CA125及T3水平均与心功能存在密切联系,三者联合检测对CHF的临床诊断与病情判断有重要价值。

Objective:To investigate the relationship between serum levels of brain natriuretic peptide(BNP),carbohydrate antigen 125(CA125),thyroid hormone(TH)and cardiac function in patients with chronic heart failure(CHF).Methods:A total of 120 patients with CHF,who were treated in Affiliated Hospital of Inner Mongolia Medical University from December 2015 to December 2017,were selected as the subjects.The cardiac function grading of the patients was New York Heart Association(NYHA)I/II with 51 cases;NYHA III with 39 cases,NYHA IV with 30 cases.Another 40 healthy volunteers,who were received physical examination in this hospital during the same period,were selected as control group.The levels of serum BNP,CA125 and TH were measured in all subjects,and their relationship with left ventricular ejection fraction(LVEF)and left ventricular end-diastolic diameter(LVEDD)was analyzed.Results:The levels of serum BNP and CA125 in the patients with different cardiac functions were significantly higher than those in the control group,and the levels of BNP and CA125 were increased with the increasing of NYHA grading(P<0.05).The level of serum T3 in the patients with NYHA III and NYHA IV was significantly lower than that in the control group,and level of T3 was gradually decreased with the increasing of NYHA grading,the difference was statistically significant among all groups(P<0.05).Pearson analysis showed that levels of serum BNP and CA125 were negatively correlated with LVEF(P<0.05),and there were positively correlated with LVEDD(P<0.05).The level of serum T3 was positively correlated with LVEF(P<0.05),and there was negatively correlated with LVEDD(P<0.05).Conclusion:Serum BNP,CA125 and T3 levels in the patients with CHF are closely related to cardiac function,and the combined detection of the three elements has great value in the clinical diagnosis and condition judgement of CHF.