Notch信号通路与血液系统和白血病形成

Role of Notch Signaling Pathway in Hematological System and Leukemia Formation

Notch基因编码着一类进化上高度保守的跨膜受体蛋白家族,其信号通路是由Notch受体、Notch配体、CSL DNA结合蛋白组成。该信号通路能够调节淋巴细胞的发育和分化过程,介导心血管系统的形成,参与肿瘤的发生和发展。近年来有研究表明,Notch信号通路在造血作用及白血病的发生过程中起关键作用。本文综述了Notch信号通路在淋巴细胞及造血干细胞的发育和分化中的作用,进一步探讨了其对造血作用和白血病发生发展的调节,以期能够对临床造血疾病的治疗提供帮助。

Notch gene encodes a family of transmembrane receptor proteins,which is evolutionarily conserved.Notch signaling pathway is composed of Notch receptor,Notch ligand and CSL DNA binding protein.The pathway is essential for development and differentiation of lymphocytes,formation of the cardiovascular system,development of cancers.Notch signaling pathway has recently been reported to be very important in hematopoiesis and leukemogenesis.This review summarized the functions of Notch in development and differentiation of lymphocytes and hematopoietic stem cell.We further discussed the regulation of Notch signaling pathway in hematopoiesis and leukemia development.We hope that this review is helpful for the treatment of hematopoietic diseases in clinical.