循环肿瘤细胞在胃癌化疗预后评估中的临床意义

Predictive Value of Circulating Tumor Cells for the Chemotherapy Response of Gastric Cancer Patients

目的:探讨检测循环肿瘤细胞对评估胃癌患者化疗敏感性和预后的临床价值。方法:选取行根治术的胃癌患者112例,术前留取血液标本进行循环肿瘤细胞检测。选取病理分期为Ⅲ期的36位患者进行术后6周期Xelox化疗,在化疗前和化疗结束后检测循环肿瘤细胞。分析循环肿瘤细胞检测值和肿瘤分期、化疗预后的关系。结果:在胃癌患者中,循环肿瘤细胞阳性率(>2)为39.29%(44/112),并且和肿瘤分期与淋巴结转移明显相关(P<0.05)。在术后行辅助化疗的胃癌患者中,循环肿瘤细胞阳性率和化疗敏感性明显相关,循环肿瘤细胞检测值动态增高的患者比降低的患者预后差(P<0.05)。结论:循环肿瘤细胞的动态监测有助于预测胃癌患者的化疗预后。

Objective:This study aims to investigate the predictive value of circulating tumor cells(CTCs)for chemotherapy response in gastric cancer patients.Methods:Totally 112 gastric cancer patients receiving operation were involved in this retrospective study.Blood samples from these patients were obtained and CTCs were counted at baseline.In 36 stageⅢgastric cancer patients of them,CTCs were longitudinally enumerated during the treatments.The relation of CTCs value and clinical data concerning patients was evaluated.Results:At baseline analysis of all patients,CTCs positivity(>2)was detected in 44 patients(39.29%),and it was correlated with the stage classification and lymph node metastasis(P<0.05).In 36 stageⅢpatients receiving 6 cycles of Xelox chemotherapy after surgery,CTCs positivity was closely correlated with the chemotherapy sensitivity.Patients with an increased change in CTC status had poorer prognosis than those with decreased changes(P<0.05).Conclusions:Evaluation of CTCs has the value of predicting chemotherapy response in patients with gastric cancer.