阿洛司琼联合微生态制剂治疗腹泻型肠易激综合征的临床研究

A Clinical Study on the Alosetron Combined with Probiotics in the Treatment of Diarrhea Predominant Irritable Bowel Syndrome

目的:探究阿洛司琼联合微生态制剂治疗腹泻型肠易激综合征的临床效果。方法:选择2016年1月-2018年1月于我院进行治疗的96例腹泻型肠易激综合征患者为研究对象,按照随机数字表法将其均分为实验组与对照组,每组各48例。对照组患者单纯使用阿洛司琼治疗,实验组患者在对照组患者基础上加用微生态制剂,两组患者治疗时间均为4周,分别于干预前及干预后对两组患者症状进行评分,使用IBS病情严重程度调查表(IBS-SSS)对两组患者干预前后治疗效果进行评估,并比较两组患者干预前后肠道乳酸杆菌、肠球菌及酵母样真菌菌群数及生活质量(SF-36)评分。结果:干预后,实验组患者症状评分及IBS-SSS量表评分均显著低于对照组(P<0.05),SF-36生理功能、心理功能及生活功能得分、乳酸菌及肠球菌菌群数均显著高于对照组,而酵母样真菌菌群数低于对照组(P<0.05)。结论:阿洛司琼联合微生态制剂治疗腹泻型肠易激综合征能够有效改善患者的肠道菌群、有效缓解临床症状,并可显著提高患者的生活质量。

Objective:To explore the clinical effect of alosetron combined with probiotics in the treatment of diarrhea predominant irritable bowel syndrome.Methods:96 patients with diarrhea-predominant irritable bowel syndrome who were treated in our hospital from January 2016 to January 2018 were divided into the experimental group and the control group according to the random number table method with 48 cases in each group.The control group was treated with alosetron alone.Patients in the experimental group were given probiotics on the basis of the control group.The treatment time of both groups was 4 weeks.The symptoms of patients were scored before and after the intervention.The therapeutic effect was evaluated by IBS-SSS.The number of intestinal lactobacillus,Enterococcus and yeast-like fungi and quality of life(SF-36)scores were compared before and after intervention between the two groups.Results:After intervention,the symptom score and IBS-SSS score ofexperimental group were significantly lower than those of the control group(P<0.05).The scores of physiological function of SF-36,mental function and life function,the number of lactic acid bacteria and Enterococcus bacteria were significantly higher than those of the control group,while the number of yeast-like fungi was significantly lower than that of the control group(P<0.05).Conclusion:Alosetron combined with probiotics can improve the intestinal flora in the treatment of patients with diarrhea-predominant irritable bowel syndrome,it can effectively alleviate the clinical symptoms and significantly improve the patients’quality of life.