以甘氨酸为核的扇形树枝状高分子荧光及载药性能研究

Fluorescence and Release Property Research of a New Fan-shape Polyamidoamine Dendrimer with a Core of Glycin

树枝状高分子(Dendrimer)是一类具有三维结构的高分子,因其链骨架有许多末端,结构形状象树枝而得名。与其他线性或枝化高分子相比具有高度的几何对称性、精确的分子结构、大量的官能团、分子内存在空腔及分子链增长具有可控性等特点。这些特点使其在许多领域有潜在的重要应用价值,成为相关领域的研究热点。如药物载体、基因转移、医疗诊断、表面活性剂、催化剂载体等。因此,研究出一种新型的树枝状高分子,具有重要的意义。目前常用的树枝状高分子的合成方法包括固相法及液相法。应用一种新思路把两者优点相结合,以甘氨酸为核,通过设计合成了末端为氨基的新的扇形树枝状高分子化合物,同时研究了它作为生物医用材料中的非病毒载体的性能。

Dendrimers are highly branched,monodisperse macromolecules with a well-defined three-dimensional structure.Since their introduction in the mid-1980s,this novel class of polymeric materials has attracted considerable attention.Dendrimers differ from many classical polymers,such as linear and branched polymers,in that they are well-defined,with the perfectly branched dendritic architecture and a high degree of molecular uniformity,as well as a highly functional surface.This unique properties have hence been validated in a substantial amount of different application fields in recent years.For example,as carriers for the development of drug delivery systems、gene delivery and medical treatment.So it is very important to synthesize a new denerimers because of their potential applications.Nowadays,the synthesis of polyamidoamine denerimers includes ' solid phase synthesis' and 'liquid phase synthesis'.A new thought of synthesis polyamidoamine denerimer by fall together this two advantage is introduced.Having glycin as the core,a new fan-shape polyamidoamine denerimers are synthesized.The Release Property are being studied too.The dendrimer were then reacted with 1- acetic-5-fluorouracil to form dendrimer- 5FU conjugates.Hydrolysis of the conjugates in a phosphate buffer solution(pH7.4) at 37℃ will release free 5FU.The dendrimer seems to be a promising carrier for the controlled release of anti-tumor drugs.