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精原干细胞体外培养的研究进展

Research Progress on the in vitro Culture of Spermatogonial Stem Cells
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摘要 精原干细胞具有自我复制和分化成精子的能力,是动物体内唯一能进行遗传信息传递的干细胞。因此,精原干细胞既是干细胞生物学的重要研究对象,又是研究精子发生、制作转基因动物和研究基因功能的重要资源。报道了精原干细胞体外培养的研究历史和最新进展,并对精原干细胞体外培养的影响因素和自我增殖的维持机制等作了综述。 Spermatogonial stem cells(SSCs),the only stem cells that are capable of transmitting genetic information to subsequent generations in adult animals,have abilities to self- renew and differentiate into spermatozoa.Therefore,SSCs are not only the study object of stem cell biology,but also the valuable resource of in vitro spermatogenesis,gene analysis and functional genomics.The study history and recent progress of in vitro culture for SSCs,and the influence factors of SSC in vitro culture and maintenance mechanisms of SSC self-renewal are reported.
作者 王庆忠
机构地区 山东潍坊学院生物工程学院
出处 《中国生物工程杂志》 CAS CSCD 北大核心 2008年第S1期220-225,共6页 China Biotechnology
关键词 精原干细胞 体外培养 进展 Spermatogonial stem cells In vitro culture Progress
分类号 Q813.11 [生物学—生物工程]
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参考文献19

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二级参考文献10

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共引文献12

中国生物工程杂志
2008年 第S1期

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