口蹄疫病毒3C蛋白酶结构及其功能在抗病毒药物中的探讨

Foot-and-Mouth Disease Virus 3C Protease:Structural and Functional Insights into an Antiviral Target

3C蛋白酶在口蹄疫病毒复制过程中起重要作用,尤其是对多聚蛋白的裂解作用。研究其结构、裂解机制以及切割方式,能更好的了解其在病毒复制中的作用和生物学功能。对阐明口蹄疫病毒3C蛋白酶基于其结构而进行的药物设计有重要现实意义。

The 3C Protease from foot-and-mouth disease is critical for viral pathogenesis,having vital roles in both the processing of the polyprotein precursor and RNA replication.The structure and proteolytic mechanism,cis/trans cleavage were knew that important to reseach functions of replication and biologic.The elucidation of the structure of FMDV 3C pave the way for structure- based drug design,having significant practical important.