摘要
分泌型磷脂酶A2(secretory Phospholipase A_2,sPLA_2)是蛇毒的一个重要组分,具有广泛的生物学活性,这些功能的本质是sPLA2分子及结构的多样性,从而引发各样的生理生化反应。本文简要综述了蛇毒sPLA_2的结构特征及分子生物学特性,着重论述了sPLA_2的生物活性与其结构之间的关系,并对其作用机制和研究热点进行了探讨。
Secretory phospholipase A_2(sPLA_2) is an important component of snake venom which has a variety of biological activities.They exert their different functions by molecular and structural diversity,eventually triggering kinds of physiological and patho-physiological effects.This review summarized the structure and biological activities of snake venom sPLA_2 with emphasizing its relationship between diverse pharmacological effects and structures.In addition,some mechanisms of sPLA_2 actions and hot research field of sPLA_2 were also discussed.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2008年第S1期251-258,共8页
China Biotechnology
