期刊文献+

胰高血糖素样肽-1生物学功能的研究进展 被引量:3

Research Progress of Glucagon Like Peptide-1 and Its Biological Functions
下载PDF
导出
摘要 胰高血糖素样肽-1(GLP-1)是一种肠促胰岛素,可以促进胰岛β细胞的增殖和胰岛素分泌,抑制胰高血糖素的分泌,抑制胃排空,显著降低2型糖尿病病人的血糖水平;此外,GLP-1对于保护心血管系统,降低心血管疾病的风险等方面具有积极作用。本文对阐述和分析了胰高血糖素样肽-1生物学功能的研究进展。 Glucagon like peptide-1(GLP-1) is an intestinal insulin that can induction of islet β –cell proliferation and insulin secretion, inhibition of glucagon recreation and slowing the gastric emptying, which significantly reduces blood glucose level in type 2 diabetes. In addition, GLP-1 has a positive role in protecting cardiovascular system and lowering the risk cardiovascular disease.
出处 《生物化工》 2017年第6期97-98,104,共3页 Biological Chemical Engineering
基金 天津市大学生创新创业训练计划项目"多拷贝功能互补型双元促胰岛素的构建及其降糖活性的研究"(201610061074)
关键词 胰高血糖素样肽-1 胰岛Β细胞 胰岛素 糖尿病 Glucagon like peptide-1 Isletβcell Insulin Diabetes
  • 相关文献

参考文献5

二级参考文献32

  • 1王中群,李丽华,严金川,徐绥宁.糖基化终末产物与动脉粥样硬化的关系[J].中国动脉硬化杂志,2015,23(1):94-100. 被引量:16
  • 2Parkes DG,Pittner R,Jodka C,et al.Insulintropic actions of exendin-4 and glucagon-like pepetide-1 in vivo and in vitro.Metab,2001,50:583-589.
  • 3Perfetti R,Merkel P.Glucagon-like peptide-1 7-36:a major regulator of pancreatic beta cell function.Eur J Endocrinol,2000,143:717-725.
  • 4Abranmsen N,Nishimurd E.Regulation of glucagons and glucagon-like peptide-1 receptor messenger RNA expression in cultured rat pancreatic islets by glucose,cyclic AMP,and glucocorticoide.Endocrinol,1995,136:1572-1580.
  • 5Gunnar S,Mehboob AH,George GH.Glucagon-like peptide-1 stimulates insulin gene promoter activity by protein kinase A independence activation of the rat insulin gene cAMP response element.Diabetes,2000,49:1156-1164.
  • 6OLOKOBA A B,OBATERU O A,OLOKOBA L B.Type 2Diabetes Mellitus:A Review of Current Trends[J].Oman Med J,2012,27(4):269-273.
  • 7WILLARD F S,SLOOP K W.Physiology and Emerging Biochemistry of the Glucagon-like Peptide-1 Receptor[J].Experimental diabetes research,2012,47(8):824-828.
  • 8MIZOKAMI A,YASUTAKE Y,GAO J,et al.Osteocalcin Induces Release of Glucagon-like Peptide-1 and Theraby Stimulates Insulin Secretion in Mice[J].Plo S one,2013,8(2):e57375.
  • 9PEYOT M L,GRAY J P,LAMONTAGNE J,et al.Glucagonlike Peptide-1 Induced Signaling and Insulin Secretion Do Not Drive Fuel and Energy Metabolism in Primary Rodent Pancreatic Beta-cells[J].PLo S One,2009,4(7):e6221.
  • 10RAMOS L S,ZIPPIN J H,KAMENETSKY M,et al.Glucose and GLP-1 stimulate c AMP production via distinct adenylyl cyclases in INS-1E insulinoma cells[J].The Journal of general physiology,2008,132(3):329-338.

共引文献13

同被引文献26

引证文献3

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部