铁代谢红细胞系调节因子与铁稳态

Erythroid Regulators in Iron Metabolism and Homeostasis

红细胞合成是人类和其他脊椎动物最耗铁的生理过程,对机体铁稳态具有重要调节作用。Erythroferrone(ERFE)是红细胞系来源的调节铁调素的主要激素。当机体存在应激性红细胞合成时,ERFE合成增加,铁调素表达受抑,可促进机体铁吸收和储铁动员,满足红细胞合成对铁的需求,但在无效红细胞生成疾病中,通过此作用也导致了铁过载的发生。ERFE抑制肝细胞合成铁调素的作用机制尚不清楚,但至少部分地依赖BMP/SMAD信号通路。ERFE对铁代谢障碍性疾病和红细胞生成紊乱性贫血有重要的诊断及治疗价值。

Erythropoiesis,the most iron-consuming physiological process in human beings and other vertebrates,plays an important role in regulating iron homeostasis.Erythroferrone(ERFE)synthesized and secreted by erythroblasts is the major erythroid regulator of hepcidin.During stress erythropoiesis,increased ERFE inhibits the expression of hepcidin,which promote intestinal iron absorption and iron mobilization from recycling macrophages and stores,and meet iron demand for erythropoiesis.However,in the ineffective erythropoiesis diseases,iron overload is also caused by this effect.The mechanism by which ERFE inhibits hepcidin is unclear,but at least it is partly dependent on the BMP/SMAD signaling pathway.ERFE has important diagnostic and therapeutic values for iron metabolism disorders and ineffective erythropoiesis anemia.