Tau蛋白寡聚体与阿尔茨海默病

Tau Protein Oligomer and Alzheimer's Disease

阿尔茨海默病(AD)是严重影响老年人健康的一种神经退行性疾病。AD主要两个病理特征是tau蛋白组成的神经原纤维缠结和β淀粉样蛋白组成的Aβ斑块。Tau蛋白是目前研究AD机制和防治药物的一个重要靶点。Tau蛋白的寡聚体形式被认为是最具神经毒性的,并且其能在神经元之间传播,诱导胞内的正常tau蛋白聚集。本综述结合近年来的文献报道,对tau寡聚体的制备手段、形成机理、神经毒性、传播机制以及治疗前景等方面做了系统总结和讨论,为人们深入认识tau寡聚体提供参考。

Alzheimer’s Disease(AD)is one of the neurodegenerative diseases that causes severe health problems of the elderly.Two main pathological features of AD are neurofilament tangles formed by tau protein and the senile plaque comprised of Aβpeptide.Tau protein is a very popular target for the studies of AD mechanisms and drug design.The oligomeric forms of tau protein are believed to be the most neurotoxic,and propagate between neurons,then inducing endogenous tau protein to aggregate.This review discusses the preparation methods,forming mechanisms,neurotoxicity,propagation and the research future of tau oligomers,which could help further understanding of tau oligomers.