成纤维细胞生长因子9在抑郁症及其运动干预调节中的作用

The Roles of Fibroblast Growth Factor 9 in Depression and Regulation of Exercise Intervention

成纤维细胞生长因子9(fibroblast growth factor 9,FGF9)是成纤维细胞生长因子(fibroblast growth factor,FGF)家族成员之一,属于一种自分泌或旁分泌生长因子。在脑组织中,FGF9主要表达于海马和皮质区,具有促进细胞增殖和维持细胞存活的功能。研究发现,FGF家族在抑郁症患者的多个脑区出现表达紊乱,FGF9在抑郁行为中扮演着负调控角色,但其介导抑郁行为的分子机制尚不清楚。本文综述了FGF9及其家族成员在抑郁中的作用;围绕其受体(FGFR)信号在中枢神经系统中的功能特点,深入分析FGF9调节抑郁行为中的作用机制;结合运动抗抑郁的神经营养假说,提出经由FGFR/GSK3β/β-catenin通路的FGF信号,可能介导抑郁症的运动干预机制的假设。这些将为FGF9介导抑郁行为和运动抗抑郁的有关研究提供理论的基础和探索的思路。

Fibroblast growth factor 9(FGF9)is a member of fibroblast growth factor(FGF)family and belongs to a kind of autocrine or paracrine growth factors.In brain tissue,FGF9 is mainly expressed in hippocampus and cortex,which can promote cell proliferation and maintain cell survival.It was found that the expression disorder of FGF family appeared in many brain regions of depression patients,and FGF9 played a negative regulatory role in depression behavior.However,the molecular mechanism of depression behavior was not fully clear.This article reviews the functional roles of FGF9 and its family members in the etiology of depression,and analyzes the functional characteristics of its receptor(FGFR)signal in the central nervous system and the regulatory mechanism of FGF9 in depression behavior.Combined with the neurotrophic hypothesis of exercise anti-depression,the hypothesis that the FGF signal via FGFR/GSK3β/β-catenin pathway may mediate the motor intervention mechanism of depression is proposed.These will provide further information in the understanding of FGF9-mediated depression behavior and exercise anti-depression.