摘要
Objective:To explore the relationship between blood lipids and serum uric acid(UA)in the elderly patients with coronary heart disease(CHD).Method:Quartered patients according to their uric acid level.Systematic review and compare lipid level among this four groups.Polynary logistic stepwise regression analysis were employed to analyze independent risk factor of coronary heart disease.Results:Serum level of triglycerides(TAG)and very low density lipoprotein cholesterol(VLDL-C)increase significantly(F=7.42,p<0.01;F=5.42,p<0.01 respectively)while high density lipoprotein cholesterol(HDL-C)and Apolipoprotein A1(Apo A1)decrease(F=5.03,p<0.01;F=7.03,p<0.01)upon elevated serum uric acid level among coronary heart disease patients.Gender(OR=0.16,95%CI 0.078~0.315,p=0.001),Ccr(OR=0.95,CI=0.935~0.969,p=0.001),associated hypertension(OR=2.23,CI=1.156~4.285,p=0.017)or DM(OR=2.44,CI=1.154~5.168,p=0.02),TC(OR=1.56,CI=1.119~2.186,p=0.009),HDL-C(OR=0.02,CI=0.004~0.076,p=0.001),UA(OR=1.09,1.086~1.094,p=0.001)are all independent risk factors for coronary heart disease.Conclusion:TAG,VLDL-C were positively related to UA while HDL-C and Apo A1were negatively linked to UA among CHD patients.Gender,Ccr,Hypertension,DM,TC,HDL-C and UA are independent risk factors for CHD while BMI,TAG,LDL-C were not.
Objective: To explore the relationship between blood lipids and serum uric acid(UA) in the elderly patients with coronary heart disease(CHD).Method: Quartered patients according to their uric acid level. Systematic review and compare lipid level among this four groups. Polynary logistic stepwise regression analysis were employed to analyze independent risk factor of coronary heart disease. Results: Serum level of triglycerides(TAG) and very low density lipoprotein cholesterol(VLDL-C) increase significantly(F=7.42, p<0.01; F=5.42, p<0.01 respectively) while high density lipoprotein cholesterol(HDL-C) and Apolipoprotein A1(Apo A1) decrease(F=5.03, p<0.01; F=7.03, p<0.01) upon elevated serum uric acid level among coronary heart disease patients. Gender(OR=0.16, 95%CI 0.078~0.315, p=0.001), Ccr(OR=0.95, CI= 0.935~0.969, p=0.001), associated hypertension(OR=2.23, CI=1.156~4.285, p=0.017) or DM(OR=2.44, CI=1.154~5.168, p=0.02), TC(OR=1.56, CI=1.119~2.186, p=0.009), HDL-C(OR=0.02, CI=0.004~0.076, p=0.001),UA(OR=1.09, 1.086~1.094, p=0.001) are all independent risk factors for coronary heart disease.Conclusion: TAG, VLDL-C were positively related to UA while HDL-C and Apo A1 were negatively linked to UA among CHD patients. Gender, Ccr, Hypertension, DM, TC, HDL-C and UA are independent risk factors for CHD while BMI,TAG, LDL-C were not.
出处
《生物技术世界》
2014年第11期116-121,共6页
Biotech World
基金
天津市卫生局科技基金(2011KZ60)
