外界刺激作用在苍白球内侧部对失神癫痫的控制机制

Controlling Mechanism of Absence Seizures by External Stimuli Applied on Globus Pallidus Interior

本文,我们建立了一个苍白球内侧部-皮层-丘脑平均场网络模型,把外界刺激电压作用在苍白球内侧部研究了失神癫痫的控制机制.研究表明,通过合适地调节电压的强度,癫痫发作可以得到有效的控制.这种调节是通过三条耦合路径之间的相互竞争实现的.我们还从模型本身出发很好地解释了这种控制原理.用到的数据都来自于临床实验数据,因此,由本文得到的结果可以推断大脑苍白球内侧部有可能成为未来深度脑刺激治疗癫痫疾病的目标区域.

In this paper, we builded a thalamocortical-globus pallidus interior network and employed the external stimuli voltage on the globus pallidus interior(GPi) to study the control mechanism of absence epilepsy seizures. We found that the seizure can be well controlled by turning the strength of voltages into suitable ranges. This regulation is achieved through the competition between three coupling pathways. We also give a good explanation of the control principle from the model itself. The data used are from the clinical trial, therefore, we can infer from the results obtained in this paper that the medial part of the globus pallidus may be the target axea for deep brain stimulation in the future.