Ⅲ型干扰素研究现状

Research status of type Ⅲ interferon

最早发现的细胞因子是干扰素(interferon,IFN),因能干扰病毒的复制和感染而得名。Ⅲ型干扰素是2003年发现的新类型,其具有IFN和白细胞介素的特点,称为IFNλs(包括IL-28A、IL-28B和IL-29)。Ⅲ型干扰素受体复合物是由IL-28Rα和IL10-Rβ组成的异源二聚体,通过Janus激酶/酪氨酸激酶(Janus kinase/signal transducer andactivator of tran-scription signaling pathway,JAK/STAT)等信号途径,发挥抗病毒、抗肿瘤和免疫调节功能。本文对Ⅲ型干扰素的研究进行综述,重点是其生物活性的最新进展。

Objective The earliest discovered cytokines are interferons(IFNs),which are known to interfere with the replication and infection of viruses. Type Ⅲ interferons with characteristics of interferons and interleukins were discovered in 2003 and called IFNλs(including IL-28 A,IL-28 B and IL-29). The receptor complex of type Ⅲ interferons is formed by a distinct heterodimer consisting of IL-28 Rα and IL-10 Rβ. Type Ⅲ interferons have antiviral,anti-tumor and immune regulation activities through JAK/STAT and other signal pathways. This paper reviews the progress in research on type Ⅲinterferons,especially that on biological activities.