线粒体能量代谢相关miRNA的研究进展

Progress in research on mitochondrial energy metabolism associated miRNAs

线粒体为真核细胞的能量工厂,其能量代谢与细胞凋亡、自噬和衰老等过程密切相关,在疾病的发生发展以及后续治疗中也发挥着重要作用。microRNAs(miRNAs)为一类广泛存在于真核生物中的单链RNA,可通过降解靶基因或抑制靶基因的翻译来调节蛋白表达。近年来多项研究表明,miRNA还可通过调节线粒体相关基因的表达,调控线粒体的结构及功能,影响线粒体的能量代谢。本文就miRNA的作用机制及其与线粒体能量代谢关系的研究进展作一综述。

Mitochondria are the energy factories for eukaryotic cells.Mitochondrial energy metabolism is closely related to the apoptosis,autophagy and aging of cells,which plays an important role in the development of disease and subsequent treatment.MiRNAs are single-stranded RNAs which exist widely in eukaryotes and modulate the expression of protein by degrading target genes or inhibiting translation.In recent years,several studies have shown that miRNA can also regulate the structure and function of mitochondria and affect the energy metabolism of mitochondria by regulating the expression of mitochondrial related genes.This paper reviews the progress in research on mechanism of miRNA and its relationship to mitochondrial energy metabolism.