低分子肝素与纳络酮联合治疗AECOPD合并II型呼吸衰竭的疗效观察

目的:观察低分子肝素与纳络酮联合治疗AE-COPD合并II型呼吸衰竭的疗效。方法:将84列AECOPD合并II型呼吸衰竭患者随机分为治疗组和对照组,每组42列,两组均给予常规治疗,治疗组给予低分子肝素5000IU(0.2ml)皮下注射12小时一次,连用7天,同时给予纳络酮(0.4mg/支)1.6mg加入生理盐水500ml持续静脉滴注,神志清楚时改为一日一次,连用7天。对照组:给予常规呼吸兴奋剂治疗。结果:治疗组患者症状缓解的时间及住院治疗时间明显短于对照组,且无血栓、出血并发症,两组比较有显著差异(P<0.05)。结论:低分子肝素与纳络酮联合治疗AECOPD合并II型呼吸衰竭疗效显著。

Objective:To observe the clinical effect of low molecular weight heparin and naloxone for the treatment of type II respiratory failure of chronic obstructive pulmonary disease(COPD). Methods:84 certifi ed patients were selected and divided into two groups according to random,treatment group and control group,42 patients in each group respectively.Both the groups were given normal treatment.IN treatment group was added with low molecular weight heparin 5000 IU(0.2ml)once time every 12 hours by subcutaneous injection,7 days for the course of treatment; at the same time,naloxone 1.6mg was added up to 500ml of sodium chloride intravenous drip,then keep up till patient come to himself,later inject naloxone once a day,a course needs about 7 days,Patients in control group were treated by routine therapy. Result:The treatment group was obviously shorter than the control group in the length of stay and the time of clinical relieve,and without thrombosis and hemorrhage. There were signifi cant difference between the two groups(<0.05). Conclusion The combination of low molecular heparin calcium and naloxone is effective for the treatment of type II respiratory failure of COPD.