口腔扁平苔藓患者40例幽门螺旋杆菌的检测及意义

Detection of helicobacter pylori in 40 cases with oral lichen planus and its significance

目的:探讨糜烂型扁平苔癣与幽门螺旋杆菌(HP)的相关性。方法:应用聚合酶链反应技术,对糜烂型扁平苔癣患者的口腔黏膜进行幽门螺旋杆菌脱氧核糖核酸的检测,比较与正常黏膜存在情况的差异。结果:对照组20例,HP呈阳性为1例。病例组40例,HP呈阳性为14例。两者存在显著性差异。结论:以糜烂型口腔扁平苔癣患者口腔黏膜中HP的存在情况为着手点,去除了胃肠道疾病的影响。正常组与糜烂型扁平苔癣病例组HP的存在有显著性差异,表明HP的存在与口腔扁平苔癣糜烂的发生密切相关。

Objective:To explore the relativity between erosive oral lichen planus(OLP)and helicobacter pylori (HP). Methods: Polymerase chain reaction (PCR) was applied to detect HP DNA on the oral mucosa of the patients with erosive OLP. Results:The difference was significant compared with the control group. 1 in 20 was HP positive in the control group. 14 in 40 were positive in the observation group. Conclusion:There is a significant difference in HP DNA between control group and observation group. HP is proved to exist in oral mucosa of OLP patients and could invade into affected site of OLP. HP is closely related to certain OLP.