155例肿瘤患者癌性贫血的相关因素分析

Related factors analysis of cancer anemia in 155 tumor patients

目的:观察化疗及其他因素对肿瘤患者血红蛋白(HGB)的影响。方法:选择我科2011年10月-2014年10月收治的155例肿瘤患者。统计性别、年龄、原发肿瘤、临床分期、分化程度、治疗方案、各周期化疗前后谷丙转氨酶、谷草转氨酶、血肌酐、血红蛋白值等资料;采用SPSS 19.0软件进行单因素分析及多因素Logistic分析,得出癌性贫血的独立危险因素。结果:肿瘤患者血红蛋白值化疗后呈逐渐下降趋势,第5个周期化疗后降至最低。化疗前,性别、年龄和肾功能是否异常是癌性贫血的相关因素,其中,女性、65岁以上和肾功能异常是独立危险因素;第1个周期化疗后,性别和肾功能是否异常是癌性贫血的相关因素,其中,女性和肾功能异常是独立危险因素;第5个周期化疗后,性别、病种、化疗方案和肾功能是否异常是癌性贫血的相关因素,但均不是独立危险因素。结论:老年女性、肾功能异常的肿瘤患者更易发生癌性贫血,应采取预防措施及适当的对症治疗。

Objective: To observe the effect of chemotherapy and other factors on hemoglobin of tumor patients.Methods: To choose 155 tumor patients and collect the data included gender,age,primary tumor,pathological staging,degree of differentiation,ALT,AST,serum creatinine,hemoglobin before and after each cycle of chemotherapy. To use single factor analysis by SPSS 19. 0 software and multivariate Logistic analysis to obtain the independent risk factors of cancer anemia. Results: Patients’ hemoglobin in pre- chemotherapy and 1st ~ 5th chemotherapy cycle gradually declined,and fell to the lowest after 5th chemotherapy cycle. Before chemotherapy,gender,age and kidney function decreasion were related factors of cancer anemia,and women,over the age of 65,kidney function decreasion were independent risk factors. After 1st chemotherapy cycle,gender and kidney function decreasion were related factors of cancer anemia,women and kidney function decreasion were independent risk factors. Conclusion: Elderly women,kidney function decreasion were more susceptible to cancer anemia.