晚期癌症患者营养状况调查及肠内肠外营养支持效果比较

Investigation on prevalence of malnutrition and exploration on effects of two nutritional supports in terminal cancer patients

目的:调查晚期癌症患者营养不良的发生情况,比较肠内营养(EN)及肠外营养(PN)支持的疗效。方法:随机选取188例住院晚期癌症患者,用营养风险筛查2002(NRS2002)量表评估患者营养状况。将诊断为营养不良的患者随机分为2组,分别给予肠内营养和肠外营养支持,观察并比较两组患者治疗前后的营养改善情况、生存质量及功能康复状况。结果:患者营养不良发生率为60.1%,≥70岁者发生率高于<70岁者(P<0.05);两组治疗前后的营养状况指标、生存质量评分和功能康复评分均有统计学差异(P<0.05),治疗后EN组营养状况指标、生存质量指标和功能康复指标均优于PN组(P<0.05)。结论:晚期癌症患者营养不良发生率高,在胃肠道功能正常时首选肠内营养支持治疗。

Objective: To investigate the prevalence of malnutrition and explore the effects of two nutritional supports in terminal cancer patients. Methods: All 188 terminal cancer patients were selected to investigate the prevalence of malnutrition by NRS2002. Patients with a diagnosis of malnutrition were divided into 2 groups randomly and accepted EN and PN supports respectively,2 weeks later,related indexes were determined including nutritional status,quality of life and functional rehabilitation. Results: The average prevalence of malnutrition was 60. 1% prevalence in patients over 70 years old was significantly higher than it in below 70 years old( P < 0. 05). There was significant difference of related indexes between pre- treatment and post- treatment in both groups( EN and PN group). Related indexes in EN group was significantly superior to those in PN group( P < 0. 05). Conclusion: There is a high prevalence of malnutrition in terminal cancer patients,and it is essential to nutritional support. The first choice of nutritional support is eternal nutrition if patients own normal digestive and absorptive functions.