业余时间体育活动与膀胱癌发生风险关系的荟萃分析

Leisure-time exercise and risk of bladder cancer:A Meta-analysis

目的:探索业余时间体育活动和膀胱癌风险的关系。方法:系统检索2014年3月10前发表在Pub Med、Embase、Cochrane Library、Web of Science、CNKI和万方数据库上关于业余时间体育活动与膀胱癌关系的文献。采用随机效应模型对合并相对危险度(RR)及其95%可信区间(CI)进行定量计算。结果:共10篇文献合计1 216 067名参与者和4 865例膀胱癌病例纳入本分析中。与不经常在业余时间进行体育锻炼的人相比,经常在闲暇时间进行体育活动的人患膀胱癌的风险降低20%(RR=0.8,95%CI:0.64~0.99),进一步偏倚分析提示不存在发表偏倚。结论:业余时间体育活动对膀胱癌有预防保护作用。

Objective: To determine the association between leisure- time exercise and bladder cancer risk. Methods: We systematically searched databases of Pub Med,Embase,Cochrane Library,Web of Science,CNKI and Wan Fang from their inception through March 10 th,2014 for articles that evaluated the association between leisure- time exercise and risk of bladder cancer. Random effects models were used to calculate the summary estimates for relative risks( RRs) and their corresponding 9 5 % confidence intervals( CIs). Results : Ten studies involving a total of 1 216 067 participants and 4 865 bladder cancer cases were included in this analysis. Meta- analysis of all included studies showed that the risk of bladder cancer among the most physically active people was decreased about 20%compared with the least active people( RR = 0. 8,95% CI: 0. 64 ~ 0. 99). No evidence of publication bias was observed from the visual inspection of the funnel plot and Begg's test. Conclusion: Our findings provide support for a protective effect of leisure- time exercise on bladder cancer.