奥沙利铂致过敏反应6例回顾性分析

Hypersensitivity reactions to oxaliplatin:A retrospective analysis of 6 cases

目的:探讨奥沙利铂致过敏反应的发生机制、临床表现及其预防和处理对策。方法:对6例奥沙利铂过敏患者的临床资料进行回顾性分析,并结合相关文献进行讨论。结果:1例患者自第2周期出现发热,体温最高38℃,无其他不适,1例患者在第10周期出现发热症状,并于第15周期出现Ⅱ度过敏反应,2例患者主要表现为全身瘙痒、皮疹,1例患者主要表现为腹痛,1例患者出现过敏性休克症状。结论:奥沙利铂过敏临床并不罕见,患者出现过敏反应的临床表现及严重程度个体差异性较大,部分患者出现严重过敏反应,临床上需引起足够重视。

Objective: To discuss oxaliplatin- induced hypersensitivity reactions mechanisms,clinical manifestation and its prevention and treatment measures. Methods: The clinical data of 6 patients with oxaliplatin- induced hypersensitivity reactions were retrospectively analyzed,and discussed in combination with related literature. Results: 1case developed fever since the second cycle,the highest temperature was 38 degrees. 1 case fever since 10 cycle,and happened II degree of allergic reactions in 15 cycle. 2 cases were mainly characterized by body itch and rash,1 case was mainly characterized by abdominal pain,1 case had symptoms of anaphylactic shock. Conclusion: Oxaliplatin-induced hypersensitivity reactions are not rare. Patients' clinical manifestations and severity of anaphylaxis have a lot of individual differences,some patients with severe allergic reactions.