摘要
CDKN2A、TP53、RB1和BRCA2是细胞周期相关基因,主要通过转录合成细胞周期相关蛋白,在细胞增殖和凋亡的调控方面发挥重要作用。并且CDKN2A、TP53、RB1和BRCA2基因在多种肿瘤的发生发展以及肿瘤的治疗和预后方面扮演重要角色。本文就近年来对CDKN2A、TP53、RB1和BRCA2在肿瘤中作用以及对患者治疗疗效和预后影响的研究进展进行综述。
CDKN2A,TP53,RB1 and BRCA2 are cell cycle-related genes,which play an important part in the regulation of cell proliferation and apoptosis. CDKN2A,TP53,RB1 and BRCA2 genes play a vital role not only on the carcinogenesis and development of multiple tumors,but also on the treatment and prognosis of tumors. This paper reviews the progress about the effect on tumor and the influence on the curative effect and prognosis of CDKN2 A,TP53,RB1 and BRCA2.
作者
贺小威
徐玲
He Xiaowei;Xu Ling(Department of Medical Oncology,the First Hospital of China Medical University,Liaoning Shenyang 110001,China)
出处
《现代肿瘤医学》
CAS
2018年第1期153-157,共5页
Journal of Modern Oncology
基金
国家自然科学基金(编号:81673025)
关键词
细胞周期相关基因
肿瘤
治疗
预后
cell cycle-related genes
tumor
treatment
prognosis
