芦荟联合重组人表皮生长因子防治鼻咽癌急性放射性皮炎的疗效观察

Efficacy of recombinant human epidermal growth factor combined with aloe in the prevention and treatment of acute radiation dermatitis of nasopharyngeal carcinoma

目的:探讨芦荟联合重组人表皮生长因子对鼻咽癌患者急性放射性皮炎的防治效果。方法:选取100例根治性放疗的鼻咽癌患者,随机分为两组。50例患者第1次放疗后涂抹重组人表皮生长因子及芦荟汁为实验组,50例仅涂抹芦荟汁为对照组。结果:实验组和对照组急性放射性皮炎发生率分别为48.0%、84.0%(P<0.01)。I-Ⅱ级放射性皮炎发生率实验组为42.0%(21/50),对照组为66.0%(33/50)。Ⅲ-Ⅳ级放射性皮炎发生率实验组为6.0%(3/50),对照组为18.0%(9/50)。实验组疼痛评分较对照组低(P<0.01)。放疗结束后随访4周,实验组患者91.7%(22/24)在1周内急性放射性皮炎病情缓解,对照组61.9%(26/42)的患者在1周内病情缓解。对照组急性放射性皮炎持续时间长于实验组(P<0.05)。结论:芦荟联合重组人表皮生长因子防治鼻咽癌急性放射性皮炎效果良好,可减轻患者痛苦、改善生活质量,为鼻咽癌患者放疗顺利进行提供保障。

Objective: To investigate the efficacy of aloe combined with recombinant human epidermal growth factor in the prevention and treatment of acute radioactive dermatitis in nasopharyngeal carcinoma patients. Methods: A total of 100 cases of nasopharyngeal carcinoma patients with radical radiotherapy were randomly divided into two groups. 50 patients were treated with recombinant human epidermal growth factor and aloe juice after first radiotherapy,and 50 cases were treated with aloe juice as the control group. Results: The rate of acute radiation dermatitis in the experimental group and the control group was 48. 0% and 84. 0% respectively( P < 0. 01). The rate of I-Ⅱ grade acute radiation dermatitis in experimental group was 42. 0%( 21/50),and the control group was 66. 0%( 33/50). The rate of Ⅲ-Ⅳ grade acute radiation dermatitis in experimental group was 6. 0 %( 3/5 0),the control group was18. 0%( 9/50). The experimental group pain score was lower than the control group( P < 0. 01). The patients were followed up for 4 weeks at the end of the radiotherapy. 91. 7%( 22/24) of the patients in the experimental group had remission within 1 week,and 61. 9%( 26/42) of the control group had been relieved within 1 week. The duration of acute radiation dematitis in the control group was longer than that in the experimental group( P < 0. 05). Conclusion:The combination of aloe and recombinant human epidermal growth factor can be effective in prevention of acute radiation dermatitis,relieve the pain of patients,improve the quality of life and provide the guarantee for the smooth progress of radiotherapy in patients with nasopharyngeal carcinoma.