胃癌免疫治疗联合化疗的临床研究进展

Clinical research progress of immunotherapy combine with chemotherapyfor gastric cancer

胃癌是我国常见的恶性肿瘤之一,虽然近年来其发病率及死亡率有所下降,但仍对我国居民健康存在严重威胁。一直以来胃癌的治疗方法以手术治疗、化疗为主,虽可使晚期胃癌患者的生存得到一定程度的改善,但其临床疗效仍有一定的局限性。肿瘤免疫治疗是通过人工干预,激发和调动自身的免疫机制,从而清除与杀伤体内的肿瘤细胞。虽然该治疗方式仍处于探索阶段,但已取得的积极成果让免疫治疗在胃癌治疗的应用中获得了一定的地位。寻找合理有效的免疫治疗方法是未来胃癌治疗的主要研究方向。本文就胃癌的免疫治疗以及免疫治疗联合化疗的临床研究进展展开综述。

Gastric cancer is one of the most common malignant tumors in China,although the incidence and mortality rates have declined in recent years,it remains a serious threat to human health. Since the conventional treatments of gastric cancer could improve the survival rate of patients to some extent,but clinical efficacy is still limited. Immunotherapy is a manual intervention approach that stimulates and regulates the immune system to clean and kill the tumor cells in human body. Although immunotherapy is in the stage of clinical research,some of the positive outcomes bring us a new dawn. Looking for a reasonable and effective immunotherapy is the main research directions in the future for gastric cancer treatment. This article reviews the progress of immunotherapy and immunotherapy combine chemotherapy for gastric cancer.