非酒精性脂肪肝与结直肠肿瘤关系的研究进展

Research progress of the relationship between non-alcoholic fatty liver disease and colorectal neoplasia

非酒精性脂肪肝(non-alcoholic fatty liver disease,NAFLD)与代谢综合征(metabolic syndrome,MS)密切相关,其发病率随着肥胖和MS发病率的增加而增加,被认为是MS的肝脏表现。近年来,大量研究显示NAFLD与结直肠腺瘤及结直肠癌的发生有关,其中机制尚未完全明确,可能与胰岛素抵抗、炎症反应、肠道菌群等因素有关。本文就NAFLD与结直肠肿瘤的关系及发病机制的最新研究作一综述。

Non-alcoholic fatty liver disease(NAFLD) is closely related to the metabolic syndrome(MS),and its incidence is increased with the increase of obesity and the incidence of MS.In recent years,a large number of studies have shown that NAFLD is closely related to the occurrence of colorectal adenoma and colorectal cancer.The mechanism is not fully clear,may be related to insulin resistance,inflammation,intestinal flora and other factors.In this article,we review the relationship and the pathogenesis of the NAFLD and colorectal neoplasia.