血清CEA、CYFAR21-1、SCC、CA125水平对晚期非小细胞肺癌放疗疗效的评估价值

Assessment Value of Serum CEA,CYFAR21-1,SCC,CA125 Levels in Efficacy of Radiotherapy for Advanced Non-small Cell Lung Cancer

目的探讨血清肿瘤标志物水平对晚期非小细胞肺癌患者放疗疗效的评估价值。方法将晚期非小细胞肺癌患者共176例,分为观察组(近期放疗有效)和对照组(近期放疗无效),采用电化学发光法检测放疗前、后血清肿瘤CEA、CYFAR21-1、SCC、CA125水平。结果 176例患者放疗有效率为58.0%,观察组放疗前血清CEA、CYFAR21-1、SCC、CA125水平分别为(33.65±5.41)ng/ml、(19.44±3.14)ng/ml、(16.87±2.74)ng/ml、(46.81±5.49)U/ml,放疗后各项标志物水平分别为(25.13±4.65)ng/ml、(12.35±4.18)ng/ml、(11.77±3.04)ng/ml、(39.67±4.63)U/ml,均明显低于放疗前,差异均有统计学意义(P<0.05);对照组放疗前血清肿瘤标志物CEA、CYFAR21-1、SCC、CA125水平分别为(46.87±5.93)ng/ml、(28.63±10.82)ng/ml、(26.46±8.68)ng/ml、(68.16±7.38)U/ml,放疗后各项标志物水平分别为(52.17±5.49)ng/ml、(46.72±11.75)ng/ml、(38.74±63.48)ng/ml、(87.34±8.16)U/ml,均明显高于放疗前,差异均有统计学意义(P<0.05);观察组放疗前各项标志物水平均低于对照组,差异显著(P<0.05);对照组放疗后标志物水平降低患者的近期疗效明显好于放疗后血清肿瘤标志物水平升高者,差异有统计学意义(χ2=76.45,P<0.05)。结论肿瘤血清肿瘤标志物CEA、CYFAR21-1、SCC、CA125的水平对晚期非小细胞肺癌患者放疗疗效具有评估价值。

Objective To explore the assessment value of serum level of tumor markers in efficacy of radiotherapy for advanced non-small cell lung cancer .Methods 176 cases of advanced non-small cell lung cancer were divided into 2 groups:the observation group ( recent radiotherapy effective ) and the control group ( recent radiotherapy invalid ) , tumor serum CEA , CY-FAR21-1,SCC,CAl25 level before and after radiotherapy were detected by electrochemiluminescence .Results Effective rate of 176 cases of patients with radiotherapy was 58.0%,serum CEA,CYFAR21-1,SCC,CA125 levels in the observation group before radiotherapy were(33.65 ±5.41) ng/ml,(19.44 ±3.14) ng/ml,(16.87 ±2.74) ng/ml,(46.81 ±5.49) U/ml,the marker levels after radiotherapy were(25.13 ±4.65) ng/ml,(12.35 ±4.18) ng/ml,(11.77 ±3.04) ng/ml,(39.67 ±4.63) U/ml, which were significantly lower than those before radiotherapy ,the differences were statistically significant (P<0.05);serum tumor markers CEA,CYFAR21-1,SCC,CA125 levels in the control group before radiotherapy were (46.87 ±5.93) ng/ml,(28.63 ± 10.82) ng/ml,(26.46 ±8.68) ng/ml,(68.16 ±7.38) U/ml,the markers levels after radiotherapy were (52.17 ±5.49) ng/ml,(46.72 ±11.75) ng/ml,(38.74 ±63.48) ng/ml,(87.34 ±8.16) U/ml,which were significantly higher than radiotherapy , the differences were statistically significant (P<0.05);the markers levels before radiotherapy in the observation group were lower than those of the control group,the difference was significant(P<0.05);short-term efficacy of patients in the control group with decreased markers levels was better than those with elevated marker levels after radiotherapy ,the difference was statistical signifi-cant(χ2 =76.45,P<0.05).Conclusion Serum tumor markers CEA,SCC,CYFAR21-1,CA125 levels has certain evaluation value in curative effect of advanced non-small cell lung cancer treated with radiotherapy .