摘要
目的探讨IL-17F、IL-17A与大肠癌发生发展的关系。方法对72例大肠癌组织中的IL-17F、IL-17A的表达水平进行免疫组化法检测,分析不同病理因素中,IL-17F、IL-17A的表达水平。结果癌组织中的IL-17F、IL-17A的表达水平均显著高于癌旁组织(P<0.05);多因素回归分析结果显示,IL-17F、IL-17A的表达水平与淋巴结转移、分化程度以及TNM分期有关(P<0.05)。结论大肠癌组织中的IL-17F、IL-17A的阳性表达率高,二者的表达均与患者的淋巴结转移、大肠癌分化程度以及TNM分期有关。
Objective To explore the relationship between the occurrence and development of colorectal cancer and IL -17F and IL-17A.Methods The expression of IL-17F and IL-17A in 72 patients with colorectal cancer were detected by immuno-histochemistry,and the IL-17F and IL-17A levels were analyzed in different pathological factors .Results The expression of IL-17F and IL-17A in cancer tissues were significantly higher than that of para-neoplastic tissues(P<0.05).Multiple factors regres-sion analysis showed that the expression of IL-17F and IL-17A was associated with lymph node metastasis , differentiation and TNM stage(P<0.05).Conclusion The positive expression rates of IL-17F and IL-17A in cancer tissues in patients with color-ectal cancer are high ,and they are associated with lymph node metastasis ,differentiation and TNM stage .
出处
《实用癌症杂志》
2014年第9期1076-1078,共3页
The Practical Journal of Cancer
基金
南京军区医药卫生科研项目(08MA035)
