淋巴管密度与鼻咽癌淋巴结转移的关系

The Correlation Between Lymphatic Vessel Density and Lymph Node Metastasis in Nasopharyngeal Carcinoma

目的探讨鼻咽癌(NPC)组织中淋巴管密度(LVD)与其淋巴结转移的关系。方法应用单克隆抗体D2-40免疫组化法,检测66例NPC组织中的淋巴管密度,另选取30例轻度鼻咽黏膜炎的鼻咽组织作为对照,分析LVD与肿瘤淋巴结转移的关系。结果鼻咽癌组织LVD高于对照组(P<0.05);鼻咽癌组织瘤周LVD明显高于瘤内LVD(P<0.01);淋巴结转移患者NPC瘤周LVD高于无淋巴结转移者(P<0.05);瘤周LVD与鼻咽癌N分期的升高呈一致性(P<0.05);此外,瘤周LVD与鼻咽癌患者年龄、性别、远处转移、临床分期及T分期无相关性(P>0.05),年龄<49岁的NPC患者瘤内LVD高于年龄≥49岁的患者(P<0.05);瘤内LVD与患者性别、肿瘤T分期、N分期、M分期及临床分期无相关性(P>0.05)。结论鼻咽癌瘤周LVD与淋巴结转移密切相关,推测瘤周LVD对该肿瘤发生颈部淋巴结转移具有重要意义。

Objective To investigate the correlation between lymphatic vessel density ( LVD) andlymph node metastasis in nasopharyngeal carcinoma .Methods Lymphatic vessel density of 66 nasopharyngeal carcinoma patients were detected by monoclonal antibody D 2-40 immunohistochemistry .30 patients with mild nasopharyngitis were selected as the control group .The correlation between LVD and lymph node metastasis were analyzed .Results The LVD in nasopharyngeal carcinoma were signifi-cantly higher than that of the control group (P<0.05);The peritumoral LVD in nasopharyngeal carcinoma were significantly high-er than intratumoral LVD ( P<0.01);pLVD increased with the N stage of tumor ( P<0.05);pLVD had no relation with age ,sex, metastasis,T and clinical stages(P>0.05);The patients under 49 had significantly higher intratumoral LVD than patients over 49(P<0.05);and intratumoral LVD had no relationwith sex ,metastasis,T,N,M and clinical stages(P>0.05).Conclusion Peritumoral LVD has a colse relationship withlymph node metastasis in NPC ,and it is of great importance for the neck lymph node metastasis of the NPC .