乳腺癌术后复发和转移的相关因素研究

Study on Related Factors of Recurrence and Metastasis of Breast Cancer after Surgery

目的:探讨乳腺癌术后复发和转移的相关因素。方法 137例乳腺癌术后患者,将术后复发转移的35例作为A组,102例未发生复发转移者作为B组。收集两组患者临床资料并进行对比,通过多因素Logistic回归分析乳腺癌复发和转移的相关因素。结果年龄<40岁患者的复发转移率为47.83%,显著高于年龄≥40岁患者的(P<0.05);肿瘤直径>5 cm患者的复发转移率为72.73%,显著高于肿瘤直径<2 cm患者的(P<0.05);淋巴结转移数目1~3个患者的复发转移率为34.15%,淋巴结转移数目>3个患者的复发转移率为50.00%,均显著高于无淋巴结转移患者的(P<0.05);CA15-3阳性患者复发转移率为38.71%,显著高于CA15-3阴性患者的(P<0.05)。结论年龄<40岁、肿瘤直径大、淋巴结转移数目多、CA15-3阳性是乳腺癌复发转移的危险因素,临床上应加强监测危险因素,强化术后放疗的抗肿瘤措施,以降低乳腺癌术后复发和转移的发生率。

Objective To explore the related factors of recurrence and metastasis of breast cancer .Methods The clini-cal data of 137 breast cancer patients was analyzed .35 cases of relapse and metastasis of breast cancer patients was group A ,102 cases non-relapse and metastasis of breast cancer patients was group B .The factors related to recurrence and metastasis of breast cancer were compared by multivariate logistic regression analysis .Results The recurrence and metastasis rate in patients with age under 40 was 47.83%,significantly higher than patients who were 40 or over 40(P<0.05);recurrence and metastasis rate of patients with tumor diameter >5 cm with was 72.73%,significantly higher than that of tumor diameter <2 cm ( P<0.05);the recurrence and metastasis rate of patients with 1-3 metastatic lymph nodes was 34.15%,that of patients with 3 metastatic lymph nodes was 50.00%,significantly higher than that of patients without lymphatic metastasis (P<0.05);recurrence and metastasis rate of CA15-3 positive patients was 38.71%,significantly higher than that of CA15-3 negative patients (P<0.05).Conclusion Under 40,the large diameter of the tumor ,larger number of lymph node metastasis ,CA15-3 positive are risk factors for relapse and metastasis of breast cancer .Monitoring and postoperative anti-tumor measures should be strengthened in clinic ,in order to re-duce recurrence and metastases of breast cancer .