胃癌和胃癌前病变中NHE1蛋白的表达及其意义

The Expression and Significance of NHE1 Protein in Gastric Cancer and Precancerous Lesions of Gastric Carcinoma

目的探讨NHE1蛋白在胃癌和胃癌前病变中的表达及意义。方法对收集的65例各类胃病标本的NHE1蛋白表达进行检测,高倍镜视野下阳性细胞数占视野10%以下视为阴性,10%以上视为阳性。结果在65例标本中,NHE1蛋白阳性表达率在正常胃黏膜中0%(0/10);异型增生20.00%(1/5);肠上皮化生23.08%(3/13);慢性萎缩性胃炎16.67%(2/12);胃癌80.00%(20/25)。胃癌与正常胃黏膜和各型胃癌前病变相比,差异具有统计学意义(P<0.01)。结论 NHE1在慢性萎缩性胃炎、肠上皮化生、异型增生中的表达不断上调,在胃癌组织中NHE1蛋白超表达;NHE1可能是肿瘤治疗的一个有效的靶点。

Objective To explore the expression and significance of NHE 1 protein in gastric cancer and precancerous lesions of gastric carcinoma .Methods Expression of NHE1 protein in 65 cases of patients ’ stomach trouble specimens were test-ed,at high magnification under the vision ,the number of positive cells of vision less than 10%was negative ,otherwise was posi-tive.Results In the 65 cases of specimens ,expression of NHE1 protein in normal gastric mucosa was 0%(0/10);dysplasia was 20.00%(1/5);intestinal metaplasia was 23.08%(3/13);clironic atrophic gastritis was 16.67%(2/12) ;gastric cancer was 80.00%(20/25).There has significant difference in the gastric cancer and normal gastric mucosa and each model of gastric pre -cancerous lesions(P<0.01).Conclusion Expression of NHE1 in clironic atrophic gastritis,intestinal metaplasia and dysplasia continuously increase ,and it overexpressed in gastric tissue .NHE1 could be an effective target for cancer treatment .