子宫内膜癌患者血清及组织中YKL-40、IGF和SA表达及其临床意义

Clinical Significance and Expression of YKL-40,IGF and SA in Serum and Tissue of Endometrial Carcinoma

目的探讨子宫内膜癌血清及子宫内膜组织中YKL-40、IGF及SA水平与其发生发展的关系。方法 76例子宫内膜癌患者作为观察组,另以76例健康同龄妇女作为对照组,然后采用ELISA法,检测两组患者血清YKL-40、IGF及SA水平并比较,另采用免疫组化检测两组子宫内膜组组织中上述指标的表达情况。结果观察组血清YKL-40、IGF-1、IGF-1R、IGF-2及SA水平均高于对照组,子宫内膜组织中其阳性率也高于对照组,且不同FIGO分期子宫内膜癌患者间也存在明显差异,经Logistic分析处理显示,上述指标均与子宫内膜癌的发生有密切关系。结论子宫内膜癌患者血清及子宫内膜组织中YKL-40、IGF及SA呈现异常的状态,且不同FIGO分期患者间差异也较为明显。

Objective To study the relationship between the expression of YKL-40,IGF and SA in serum and tissue of endometrial carcinoma and its development .Methods 76 patients with endometrial carcinoma were selected as the observation group,and 76 healthy women at the same age were selected as the control group ,and the serum YKL-40,IGF and SA levels of the 2 groups were compared ,immunohistochemical method was used to compare YKL-40,IGF and SA levels in endometrial tissues , and the relationship between those indexes and disease were analyzed by the Logistic analysis .Results The serum YKL-40,IGF-1,IGF-1R,IGF-2 and SA levels of the observation group were all higher than those of the control group ,positive rates in endome-trial tissues were all higher than those of the control group ,and the detection results in the observation group at different FIGO sta-ges of endometrial carcinoma had significant differences .Those indexes all had close relationship with the development of endome-trial carcinoma by Logistic analysis ,all P<0.05.Conclusion YKL-40,IGF and SA in the serum and tissue of patients with en-dometrial carcinoma have abnormal level ,and patients at different FIGO stages have significant difference .