肠外营养起始时间对胃癌根治术患者术后恢复的影响

Effect of Different Parenteral Nutrition Starting Time on Postoperative Recovery of Gastric Cancer Patients Treated with Radical Gastrectomy

目的探究不同肠外营养起始时间对胃癌根治术患者术后恢复的影响。方法选取2009年10月-2012年10月经胃癌根治术治疗的胃癌患者60例作为临床研究对象,并随机分为观察组和对照组,每组各30例。观察组患者于术后48 h内给予肠外营养,对照组患者于术后72 h给予肠外营养。观察并比较2组患者术后的恢复情况,并将2组患者术后免疫功能及营养状况进行评价。结果观察组患者术后肠功能恢复时间、排气时间、住院时间均明显短于对照组;2组患者术后CD3、CD4、CD8、CD4/CD8较术前均明显升高,观察组患者术后CD3、CD4、CD8、CD4/CD8参数分别为(67.03±6.81)%、(49.66±0.28)%、(19.63±2.88)%、(2.51±0.33)%,均明显高于对照组;观察组术后PAB、ALB、TF等营养指标也高于对照组,P<0.05,差异具有统计学意义。结论早期肠外营养治疗对胃癌根治术后患者的临床结局较好,实施最佳时间以术后48 h内为宜,对术后免疫功能及营养状况的改善具有显著的作用,值得在临床上广泛应用。

Objective To explore and analyze the different parenteral nutrition starting time on postoperative recovery of gastric cancer patients treated with radical gastrectomy .Methods 60 cases of gastric cancer patients treated with radical gastrec-tomy were randomly divided into the observation group and the control group ,30 cases in each group .The observation group was given parenteral nutrition within 48 h after surgery ,the control group were treated with parenteral nutrition 3 d after surgery .Re-covery was observed and postoperative immune function and nutritional status of the 2 groups were evaluated .Results Postopera-tive bowel function recovery time , exhaust time , length of hospital stay in the observation group were significantly shorter than those of the control group;CD3,CD4,CD8,CD4/CD8 the 2 groups increased significantly after surgery ,and CD3,CD4,CD8, CD4/CD8 parameters(67.03 ±6.81)%,(49.66 ±0.28)%,(19.63 ±2.88)%, (2.51 ±0.33)% in the observation group were significantly higher than those of the control group after surgery;PAB、ALB and TF in the observation group were higher than those of the control group after surgery ,P<0.05,there had statistical difference .Conclusion Early parenteral nutrition therapy for gastric cancer patients after radical surgery has good clinical outcome ,it is advisable to implement within 48 h after surgery .It can improve the postoperative immune function and nutritional status ,and it is worthy of clinical application .