原发性肝癌患者介入治疗前后血清Dickkopf-1表达变化

Changes of Serum Dickkopf-1 Level before and after Intervention Therapy for Primary Liver Cancer

目的观察原发性肝癌患者介入治疗前后血清Dickkopf-l(DKKl)表达水平的变化。方法采用ELISA法,检测40例健康体检者(对照组)以及87例原发性肝癌患者介入治疗前后血清DKKl水平并进行比较。结果对照组与Ⅱ、Ⅲ期原发性肝癌患者血清DKK1水平比较差异有统计学意义(P<0.05);原发性肝癌患者介入治疗后血清DKK1水平与治疗前比较,差异有统计学意义(P<0.05)。结论 DKK1可以作为评价原发性肝癌疗效和预后的指标。

Objective To observe the changes of serum Dickkopf-1 (DKK1) level before and after intervention therapy for primary liver cancer .Methods Serum DKK1 levels in 40 healthy patients ( control group ) and 87 primary liver cancer pa-tients before and after intervention therapy were compared .Results There was significant difference in the serum DKK 1 level a-mong control group,stage Ⅱand Ⅲprimary liver cancer patients (P<0.05).The serum DKK1 level was significantly different before and after the intervention therapy (P<0.05).Conclusion DKK1 can be used as a predictor for the prognosis of primary liver cancer .