妊娠滋养细胞肿瘤患者的治疗方案研究

The Research of Different Treatment for Gestational Trophoblastic Neoplasia

目的探讨对妊娠滋养细胞肿瘤患者应用不同规范化方案治疗的疗效。方法对80例妊娠滋养细胞肿瘤患者分别采用CMV(卡铂、氨甲蝶呤、长春新碱)方案治疗、双枪(5-氟尿嘧啶、更生霉素)治疗及化疗联合手术治疗,观察比较3种治疗方案的疗效和副作用。结果 CMV方案的总有效率和总治愈率均高于双枪方案,在总有效率上具有统计学差异(P<0.05);而相对双枪方案,CMV方案治疗副作用较少,在恶心、呕吐反应和脱发副作用指标上差异明显(P<0.01)。单纯化疗方案的综合总有效率较化疗合并手术低,且具有统计学差异(P<0.05)。化疗合并手术治疗副作用较单纯化疗方案偏低,且差异有统计学意义(P<0.05)。结论在单纯运用化学治疗方案中,CMV方案在总有效率、安全性方面优于双枪方案,而化疗联合手术治疗是最佳的治疗方案,但也要考虑个体的差异。

Objective To explore the curative effects of different standardized treatment for gestational trophoblastic neo -plasia.Methods 80 cases gestational trophoblastic neoplasia patients respectively received CMV (carboplatin,methotrexate,vin-cristine) treatment,double gun (5-fluorouracil,actinomycin d) treatment,and chemotherapycombined with surgery ,efficacy and side effects of the 3 treatment were compared .Results Total effective rate and total cure rate of CMV scheme were higher than those of the double gun scheme,there was statistical differences in total effective rate (P<0.05);And compared with double gun,CMV had less side effect,and nausea,vomiting and hair loss index of the 2 groups had significant difference (P<0.01). Comprehensive total effective rate of pure chemotherapy regimens was lower than that of chemotherapy combined with surgery , there was statistical difference (P<0.05).Chemotherapy combined with surgical treatment had less side effects than simple chemotherapy regimens,and the difference was statistically significant (P<0.05).Conclusion In the simple use of chemother-apy treatment ,CMV scheme is superior to double gun in the total effective rate and security ,and surgery and chemotherapy is the best treatment ,but individual difference has to be considered .